Verschiedenes » Methotrexat

Wichtig: Ich will hier auf keinen Fall Methotrexat propagieren. Sammele nur mal ein paar Informationen...

Lack of ageing with long term methotrexate: objective measurements of cognition, audiometry, and sleep
https://ard.bmj.com/content/77/Suppl_2/1305.2

Propensity‐adjusted association of methotrexate with overall survival in rheumatoid arthritis
https://onlinelibrary.wiley.com/doi/full/10.1002/art.37723

Identification of methotrexate as a heterochromatin-promoting drug
https://www.nature.com/articles/s41598-019-48137-w

@mithut

Ist mir klar. Pures Gift.
Ist aber bekanntlich immer auch eine Frage der Dosis.

Im Rundwurm beschleunigt Folat die Alterung:

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model
https://bmcbiol.biomedcentral.com/articl...1741-7007-10-67

Folate status of gut microbiome affects Caenorhabditis elegans lifespan
https://link.springer.com/article/10.1186/1741-7007-10-66

Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis
https://www.sciencedirect.com/science/ar...211124716300298

Methotrexat wirkt längst nicht nur als Folsäure-Antagonist:

Much more than you expected: The non-DHFR-mediated effects of methotrexate
https://www.sciencedirect.com/science/ar...304416516305086

Ob MTX wirken wird, sieht man rasch - nur wenn sich das Methylom ändert, wird eine Wirkung eintreten:

Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis
https://academic.oup.com/rheumatology/ar.../6/1364/5584767

MTX wirkt gegen globale Hyopmethylierung:

Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate
https://link.springer.com/article/10.1186/s13075-015-0748-5

Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat
https://www.sciencedirect.com/science/ar...166432807004032

Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model
https://www.sciencedirect.com/science/ar...006295219300486

Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study
https://link.springer.com/article/10.1186/ar2765

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
https://www.nejm.org/doi/full/10.1056/NEJMoa1809798