RE:News aus der Forschung 2023 - 13

"Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses"
> https://www.nature.com/articles/s41551-023-01086-2

Was sagt ihr?

A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging
https://www.nature.com/articles/s41467-0...DeuHscDqa9zw6NA

Vorgänger: 10.11.2023, u. a. mit Anti-Alterungsforschung und Durchbruch in Köln

"Neue Technik soll Lücke in der Reanimation schließen. Mediziner am Uniklinikum Leipzig entwickeln in einem interdisziplinären Kooperationsprojekt für Ersthelfer ein Messgerät, das anzeigt, ob die Herzdruckmassage für ausreichend Hirndurchblutung sorgt. Herzstiftung fördert mit 95.000 Euro"
Quelle: Wiederbelebung bei Herzstillstand: Mit dem „Brainsaver“ Hirnschäden vermeiden von Michael Wichert, 11.12.23
Kommentar:
Das scheint mir eine wichtige Neuerung zu sein. Ich weiß aber nicht viel darüber zu schreiben.

Polygenic prediction of human longevity on the supposition of pervasive pleiotropy
M.Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong Zhang
medRxiv 2023.12.10.23299795; doi: https://doi.org/10.1101/2023.12.10.23299795



Edit: Siehe auch:
Die Statistik der Sterbewahrscheinlichkeit

Volltext Link von David Sinclair.

The Information Theory of Aging
https://www.nature.com/articles/s43587-0...BopUlqH9I-0k%3D

Nectandrin B significantly increases the lifespan of Drosophila - Nectandrin B for longevity

Zitat

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Phytochemicals are increasingly recognized in the field of healthy aging as potential therapeutics against various aging-related diseases. Nutmeg, derived from the Myristica fragrans tree, is an example. Nutmeg has been extensively studied and proven to possess antioxidant properties that protect against aging and alleviate serious diseases such as cancer, heart disease, and liver disease. However, the specific active ingredient in nutmeg responsible for these health benefits has not been identified thus far. In this study, we present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. This result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related degeneration.

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https://www.aging-us.com/article/205234/text

Kommentar: Nutmeg = Muskatnuss. Muskatnuss ist meines Wissens ab einer gewissen Dosierung auch giftig.

Ich würde von Fruchtfliege nicht direkt auf den Menschen rückschließen wollen.

Nasenpopeln ab jetzt gestrichen:

https://www.msn.com/de-de/gesundheit/med...414cb819f&ei=28

Zitat von Julie im Beitrag #308

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Nasenpopeln ab jetzt gestrichen:

https://www.msn.com/de-de/gesundheit/med...414cb819f&ei=28

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Vibrierende „Satt-mach-Kapsel“ entwickelt
"Ein Appetitzügler der mechanischen Art: Forscher haben eine elektronische Kapsel entwickelt, die nach der Einnahme durch Vibrationen im Magen ein Sättigungsgefühl auslöst. Bei Tests an Schweinen konnten die Kapseln die Nahrungsaufnahme um 40 Prozent reduzieren, waren gut verträglich und wurden problemlos wieder ausgeschieden. Das Konzept könnte vor allem für stark übergewichtige Menschen eine minimalinvasive Behandlungs-Alternative gegenüber Medikamenten oder chirurgischen Eingriffen darstellen. Durch die relativ unkomplizierte Technik wären die Kapseln dazu auch für eine preisgünstige Massenproduktion geeignet, sagen die Entwickler."
https://www.wissenschaft.de/technik-digi...sel-entwickelt/

Also wenn man abnehmen kann, indem der Magen vibriert und so ein Sättigungsgefühl vorgetäuscht wird, könnte man dann nicht einfach einen Vibrat..äh Vibrationsplatte auf den Bauch legen, um ein Sättigungsgefühl zu erreichen? Eine kleine Silberoxidbatterie zu schlucken, welche in der Kapsel ist, klingt nicht so gesund für mich.

Eine Zeit lang waren ja diese Vibartions - Platten In zum draufstellen und abnehmen. Aber da ich gerade wenig von Ihnen höre, wird die Ganzkörpervibration zum Abnehmen vermutlich wenig Erfolg gehabt haben, sonst würde es jetzt wohl jeder durchführen.
https://www.praxisvita.de/power-plate-sc...sund-17290.html
Vibrationsplatten

Unraveling the causal genes and transcriptomic determinants of human telomere length
https://www.nature.com/articles/s41467-023-44355-z

NADase CD38 is a key determinant of ovarian aging
https://www.nature.com/articles/s43587-023-00532-9

Deciphering the mechanisms, biochemistry, physiology, and social habits in the process of aging Aging process: Deciphering the mechanisms, biochemistry, physiology, and social habits
https://www.sciencedirect.com/science/ar...950307823000036

https://www.cancerhealth.com/article/two...clinical-trials
"mRNA Cancer Vaccines Advance to Next Stage of Clinical Trials"

Parishin treatment alleviates cardiac aging in naturally aged mice

Zitat

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Parishin treatment improved cardiac function, ameliorated aging-induced cardiac injury, hypertrophy, and fibrosis, decreased cardiac senescence biomarkers p16Ink4a, p21Cip1, and IL-6, and increased the “longevity factor” SIRT1 expression in heart tissue. Furthermore, the transcriptomic analysis demonstrated that parishin treatment alleviated the cardiac aging-related Gja1 downregulation and Cyp2e1, Ccna2, Cdca3, and Fgf12 upregulation in the heart tissues. The correlation analysis suggested a strong connection between the anti-aging effect of parishin and its regulation of gut microbiota and metabolism in the aged intestine.

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https://www.cell.com/heliyon/fulltext/S2405-8440(23)10178-2

AST-001 Improves Social Deficits and Restores Dopamine Neuron Activity in a Mouse Model of Autism

Zitat

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social communication and social interaction, restricted and repetitive behavior, and interests. The core symptoms of ASD are associated with deficits in mesocorticolimbic dopamine pathways that project from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC). AST-001 is an investigational product currently in a phase 3 clinical trial for treating the core symptoms of ASD, with L-serine as the API (active pharmaceutical ingredient). Because the causes of ASD are extremely heterogeneous, a single genetic ASD model cannot represent all autism models. In this paper, we used the VPA-exposed model, which is more general and widely used than a single genetic model, but this is also one of the animal models of autism. Herein, we conducted experiments to demonstrate the efficacy of AST-001 as L-Serine that alters the regulation of the firing rate in dopamine neurons by inhibiting small conductance Ca2+-activated K+ channels (SK channels). Through these actions, AST-001 improved sociability and social novelty by rescuing the intrinsic excitabilities of dopamine neurons in VPA-exposed ASD mouse models that showed ASD-related behavioral abnormalities. It is thought that this effect of improving social deficits in VPA-exposed ASD mouse models is due to AST-001 normalizing aberrant SK channel activities that slowed VTA dopamine neuron firing. Overall, these findings suggest that AST-001 may be a potential therapeutic agent for ASD patients, and that its mechanism of action may involve the regulation of dopamine neuron activity and the improvement of social interaction.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10741043/

Kommentar: L-Serin, wie hervorgehoben.