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#101 RE: News aus der Forschung von Joker 07.10.2019 18:33

Man muss eben sehen, dass die ganze NAD-Geschichte mehr oder weniger wieder zum wichtigen Thema Retrotransposon führt.

Sirtuin 6 braucht als Cofaktor NAD+, um unseren Erzfeind Retrotransposon stillzulegen, dies hatte ich im anderen Thread bereits erwähnt.

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406663/

Da NAD+ mit dem Alter immer weiter abnimmt, nimmt auch die Stärke des vorhandenen Sirtuin 6 ab, somit hat das Retrotransposon dann freie Bahn, um die DNA zu zerstören.

Da es auch einen zweiten Weg zur Hemmung des Retrotransposon gibt - die Isoflavone - ist das NAD+ (zusammen mit SIRT6) nur eine von zwei Möglichkeiten. Man kann sich für einen der beiden Wege entscheiden oder beides parallel machen.

Ich persönlich fahre gerade beide Wege parallel, seit mir der Mechanismus bewusst wurde (also sehr kurze Zeit!)! Für die Sirtuin-6-Aktivierung nehme ich z.Zt. Nicotinamid-Ribosid mit Resveratrol und Cyanidin in Kombi.

#102 RE: News aus der Forschung von Speedy 18.10.2019 03:52

High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet
https://www.mdpi.com/2072-6643/11/10/2439/htm

#103 RE: News aus der Forschung von Speedy 21.11.2019 01:22

Hiermit käme man wirklich ''günstig'' auf genau die Mengen die David Sinclair persönlich nimmt. Aber keine Ahnung, ob das Produkt wirklich was taugen wird.
https://www.donotage.org/product-page/pr...nt-365-capsules

#104 RE: News aus der Forschung von Speedy 17.12.2019 03:24

Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902345/

#105 RE: News aus der Forschung von Speedy 17.12.2019 03:31

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice.
https://www.ncbi.nlm.nih.gov/pubmed/31818774/

#106 RE: News aus der Forschung von Speedy 06.01.2020 17:03

The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD+ Level Is Lower than the Sirtuin-Saturating Concentrations.
https://www.mdpi.com/1422-0067/21/1/142/htm

#107 RE: News aus der Forschung von Speedy 15.02.2020 03:36

NAD+ Repletion Rescues Female Fertility during Reproductive Aging
https://www.cell.com/cell-reports/fullte...LKQ7Hlw.twitter

#108 RE: News aus der Forschung von Speedy 15.02.2020 16:14

Man muss aber auch sagen, dass NMN anscheinend keine Auswirkung auf die Lebensspanne von Mäusen hat.
http://genomics.senescence.info/drugs/dr...0mononucleotide

#109 RE: News aus der Forschung von Speedy 16.02.2020 03:58

Zitat von Speedy im Beitrag #108
Man muss aber auch sagen, dass NMN anscheinend keine Auswirkung auf die Lebensspanne von Mäusen hat.
http://genomics.senescence.info/drugs/dr...0mononucleotide

NMN würde dann in erster Linie in Richtung Gesund Altern gehen.

#110 RE: News aus der Forschung von Fichtennadel 11.03.2020 10:30

https://www.cell.com/cell-reports/fullte...1247(20)30083-8

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

Summary

Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD+). Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals.

#111 RE: News aus der Forschung von KarinZ 13.03.2020 01:57

avatar

Zitat von Speedy im Beitrag #109

NMN würde dann in erster Linie in Richtung Gesund Altern gehen.


Sich fit halten, viel Bewegung und ausgeglichen Essen sollte doch schon ausreichen. Mittelchen allein machen da keinen oder kaum einen Unterschied.

#112 RE: News aus der Forschung von Speedy 23.04.2020 21:27

NAD on the rise again
https://www.nature.com/articles/s42255-020-0197-6


A new pathway for NAD+ biosynthesis!?
https://www.youtube.com/watch?time_conti...eature=emb_logo

#113 RE: News aus der Forschung von Speedy 05.05.2020 04:25

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging
https://www.sciencedirect.com/science/ar...097276520302367

#114 RE: News aus der Forschung von Speedy 09.05.2020 04:05

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
https://www.sciencedirect.com/science/ar...hZrfL-ChSo6KvDk

#115 RE: News aus der Forschung von Fichtennadel 16.05.2020 11:29

https://phys.org/news/2020-05-vitamin-b3...-metabolism.amp

Vitamin B3 revitalizes energy metabolism in muscle disease
1 day ago
University of Helsinki




An international team of scientists, led by University of Helsinki reported that vitamin B3, niacin, has therapeutic effects in progressive muscle disease. Niacin delayed disease progression in patients with mitochondrial myopathy, a progressive disease with no previous curative treatments.

Vitamin B3 forms have recently emerged as potent boosters of energy metabolism in rodents. These vitamins are precursors for NAD+, a molecular switch of metabolism between fasting and growth modes.

As fasting has been shown promote health and longevity in for example mice, a variety of "NAD boosters" are being developed. However, whether actual NAD+ deficiency exists in human disease, and whether NAD+ boosters could have curative effects in patients with degenerative diseases, has remained elusive.

In the current publication, a collaborative team of investigators led by academy professor Anu Suomalainen-Wartiovaara and academy research fellow Eija Pirinen report lowered NAD+ levels in both blood and muscle of mitochondrial myopathy patients.

"The disease is characterized by progressive muscle weakness, exercise intolerance and cramps. Currently, no treatments that would slow down disease progression exist," says Suomalainen-Wartiovaara.

Niacin—a promising treatment option

Pirinen and colleagues report that niacin treatment efficiently increased blood NAD+ both in patients and healthy subjects. Niacin restored NAD+ in the muscle of the patients to the normal level and improved strength of large muscles and mitochondrial oxidative capacity. Overall metabolism shifted towards that of normal subjects.

The results of this open pilot study revealed that niacin is a promising treatment option for mitochondrial myopathy. The authors emphasize, however, that niacin and NAD+ are efficient metabolic modifiers and niacin treatment should be cautiously applied only, when NAD deficiency is detected for example in the patient's blood.

"Our results are a proof-of-principle that NAD+ deficiency exists in humans and that NAD+ boosters can delay progression of mitochondrial muscle disease," Suomalainen-Wartiovaara comments.

"The study is a significant leap in the development of targeted therapy options for energy metabolic diseases," Suomalainen-Wartiovaara continues.

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