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#41 RE: Senolysis Program von Prometheus 05.09.2018 16:55

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#38

Zitat von Dr.Faust im Beitrag #38

So einfach? Bis auf das mir unbekannte Myricetin nimmt man das doch ohnehin.
Ist da was dran?



Myricetin und Gamma-Tocotrienol sind potentiell Senolytika.

Warum die Einnahme täglich und niedrig dosiert erfolgen soll, ist mir allerdings ein Rätsel.
Die Kombination mit Antioxidanzien ist auch nicht gerade glücklich! Wenn seneszente Zellen "eliminiert" werden sollen, behindern Antioxidantien (insbesondere NAC und Tocopherol!) die dafür erforderliche Apoptose:

Zitat
Antioxidants such as α-tocopherol, which partition into the lipid compartment of cells, or N-acetylcysteine, a free radical scavenger that partitions into the aqueous phase of the cytosol, can delay or inhibit apoptosis


https://academic.oup.com/jn/article/134/11/3179S/4688577


P.S.: Hier geht es zum Myricetin-Thread:
Myricetin

#42 RE: Senolysis Program von Fichtennadel 09.10.2018 11:42

http://ergo-log.com/fisetin-the-life-ext...m-the-body.html
https://www.ebiomedicine.com/article/S23...0373-6/fulltext

FISETIN wurde als potentes Senolytikum identifiziert, dass sowohl health- und lifespan verlängert. @Prometheus


Natural senolytics

The researchers wondered whether natural senolytics actually exist. Senolytics are substances that clean up the sensecent cells in the body. The accumulation of these outdated cells, which can no longer do their job well, is an important factor in the aging process, that makes tissues lose their function. Anti-aging researchers hope that senolytics will not only increase our life span, but will increase our health span as well.

It's not difficult to recognize a senescent cell. It produces more of the enzyme senescence-associated beta-galactosidase than a cell that is still functioning properly.

The researchers used this principle, and screened a number of natural compounds with a suspected anti-aging effect. They exposed cells in which they could measure the production of senescence-associated beta-galactosidase to these compounds, and discovered two compounds that reduced the production of that aging enzyme: curcumin and fisetin. Of these two, fisetin was the most promising.

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