RE: Long Covid - 28

Multi-Omics Reveals Dysregulated Neurotransmitter Systems in Aging and CNS Disorders
https://onlinelibrary.wiley.com/doi/full...bzrYw7qdrIlYqUQ

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We conclude that post-infectious myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of severe acute respiratory syndrome coronavirus 2 feature a specific central neurotransmitter pattern involving noradrenergic but not dopaminergic deficiency. The noradrenergic abnormality is associated with major symptoms such as post-exertional malaise.

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Central noradrenergic deficiency in post-infectious chronic fatigue: neurobehavioral correlates
https://academic.oup.com/braincomms/adva...724?login=false

Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
https://www.researchsquare.com/article/rs-9702020/v1

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LC TSPO availability did not differ from HCs in any studied brain area. However, lower WM TSPO availability in individuals with longer LC duration suggests COVID-19-associated neuroinflammation may subside with time, while the association between limbic TSPO availability and LC severity may imply a role for limbic activity in LC symptomology.

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Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study
https://link.springer.com/article/10.100...f6aOlqOZjiOmGzA

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L-citrulline supplementation for three months decreased ICAM-1 and increased 6MWT.

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Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial
https://www.mdpi.com/2072-6643/18/11/1706

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Long COVID features autoantibodies targeting neural and vascular tissues
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Patients’ IgG shows increased ADCP activity against MED20
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Passive transfer of IgG induces pain and fatigue-like phenotypes in mice
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Mouse pain behavior after IgG transfer correlates with patient-reported chronic pain

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A causal link between autoantibodies and neurological symptoms in long COVID
https://www.sciencedirect.com/science/ar...?dgcid=coauthor

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Developmental Spike exposure induces early cortical and hippocampal gliosis.
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Developmental SARS-CoV-2 Spike protein exposure induces early synapse loss.
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Developmental SARS-CoV-2 Spike protein exposure causes decreased seizure threshold.
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SARS-CoV-2 Spike protein induces a persistent gliosis in the brains of male mice.
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SARS-CoV-2 Spike protein induces late cognitive impairment in male mice.

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Exposure to SARS-CoV-2 Spike protein during development induces astrogliosis, synapse loss and long-term cognitive dysfunction in mice
https://www.sciencedirect.com/science/ar...5477?via%3Dihub

Single-cell profiling of innate and adaptive immune dysregulation in Long COVID
https://www.biorxiv.org/content/10.64898/2026.06.04.730206v1

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In this community-based target-trial emulation, receiving a third COVID-19 vaccine dose did not meaningfully reduce 6- or 12-month long COVID incidence compared with completing only a primary series.

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Effect of a third COVID-19 vaccine dose on the incidence of Long COVID among adults who completed a primary vaccine series: a target trial emulation in a community-based cohort
https://www.sciencedirect.com/science/ar...264410X26004743

Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial
https://www.sciencedirect.com/science/ar...666776226001560

Zitat von Speedy im Beitrag #684

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Zitat

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In this community-based target-trial emulation, receiving a third COVID-19 vaccine dose did not meaningfully reduce 6- or 12-month long COVID incidence compared with completing only a primary series.

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Effect of a third COVID-19 vaccine dose on the incidence of Long COVID among adults who completed a primary vaccine series: a target trial emulation in a community-based cohort
https://www.sciencedirect.com/science/ar...264410X26004743

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Was ist da das Ergebnis? Die dritte ist nicht schlechter als die zweite? Akademiker neigen zur dritten. Das Vertrauen ist einfach nicht mehr da! Auch im kommenden Spannungsfall wo jeder zum Soldaten wird und es dulden muss, NEIN!

Zitat von Speedy im Beitrag #685

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Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial
https://www.sciencedirect.com/science/ar...666776226001560

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Studie zeigt gestörten Energiestoffwechsel des Gehirns bei Menschen mit Post-COVID

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Dadurch konnten die Forschenden bei Menschen mit Post-COVID ein reduziertes Verhältnis von ATP zu PCr (ATP/PCr) nachweisen. Das spricht dafür, dass die Bereitstellung von Energie für den Zellstoffwechsel im Gehirn beeinträchtigt sein könnte. Die Veränderungen zeigten sich in einem ausgedehnten Bereich um den cingulären Cortex, einer Hirnstruktur, die unter anderem an der Steuerung und Organisation von Denkvorgängen beteiligt ist. „Die Daten deuten darauf hin, dass es nicht um eine isolierte Veränderung geht, sondern um ein größeres vernetztes System im Gehirn“, sagt Dr. Wolfgang Weber-Fahr, Arbeitsgruppenleiter am ZI.

Besonders relevant: Niedrigere ATP/PCr-Werte im vorderen cingulären Cortex gingen mit einem schlechteren Abschneiden in den kognitiven Tests einher. „Wir sehen einen Zusammenhang zwischen Energiemarkern im vorderen cingulären Cortex und der kognitiven Leistung. Das deutet darauf hin, dass eine gestörte Bereitstellung von Energie in dieser Hirnregion zu den Denk- und Konzentrationsproblemen bei Post-COVID beitragen könnte“, sagt Dr. Claudia Schilling, Leiterin des Schlaflabors am ZI.

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https://nachrichten.idw-online.de/2026/0...-mit-post-covid

An Aging Clock Based on Immune Repertoire Features: COVID-19 Accelerates Aging
https://onlinelibrary.wiley.com/doi/full...wn2OhShv_QySVBw

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The study indicates that in a fraction of COVID-19 affected participants low selenium/SELENOP levels in combination with SELENOP-specific autoantibodies are associated with a two times higher prevalence of persistent fatigue after SARS-CoV-2 infection.

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Low serum selenium combined with SELENOP-autoantibodies are associated with persistent fatigue after SARS-CoV-2 infection
https://www.sciencedirect.com/science/ar...213231726002727

Folic Acid and Endothelial Dysfunction in COVID-19
https://www.mdpi.com/2075-1729/16/7/1116

Early vitamin B12 treatment mitigates hippocampal neuroinflammation and neurodegeneration in a hamster model of long COVID
https://www.researchsquare.com/article/rs-9912983/v1

Early ist das wichtige hier.

Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms
https://www.thelancet.com/journals/ebiom...dlqcrBlKvIkjl_w

DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae
https://www.cureus.com/articles/513868-d...ric-sequelae#!/

Altered TRPM3-Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post-COVID-19 Condition Patients
https://onlinelibrary.wiley.com/doi/10.1002/eji.70240
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Den TRPM3 - Channel kann man unter anderem mit Nifedipin und Pregnenolonsulfat (mit Pregnenolon eher weniger) aktivieren.

IL-6 family cytokines behind acute COVID-19 and Long COVID syndrome: Mechanisms, biomarkers, and intervention strategies
https://www.sciencedirect.com/science/ar...167488926000972

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
https://www.nature.com/articles/s41467-026-75725-y

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Combinatorial tetramer deep-profiling of viral-specific T cells in long COVID (LC)
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LC features more cytolytic CD8+ T cells against SARS-CoV-2, CMV, and EBV
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Females with LC exhibit most terminally differentiated cytolytic CD8+ T cells
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Inability to resolve acute cytolytic CD8+ T cell response may be a feature of LC

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Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID
https://www.cell.com/cell-reports-medici...3791(26)00363-0

Host–virus resilience networks and viral inflammaging circuits in aging and long COVID: a CMV-centered perspective
https://www.frontiersin.org/journals/cel...26.1896480/full

The Post-COVID syndrome caused by excessive inflammation: pathogenesis, potential targets and therapeutic agents
https://www.frontiersin.org/journals/pha...26.1852220/full

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID
https://www.biorxiv.org/content/10.64898/2026.08.07.743616v1