Zitat • Mitochondrial quality control is organized as a hierarchical redox network. • Reactive oxygen species, NAD+, and calcium act as integrated regulators. • Defective mitochondrial quality control contributes to major human diseases
Zitat Together, these findings show that mitochondrial aging creates a vulnerable metabolic environment that, combined with specific triggers, can push cells toward early tumorigenesis, offering a new framework for understanding and intervening in age-related cancer risk.
Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State https://www.mdpi.com/2079-7737/15/16/1443
Zitat Together, our findings identify mitochondrial citrate as a redox-sensitive second messenger linking mitochondrial superoxide stress to durable epigenetic and mitohormetic remodeling.