RE: Tipps gegen Falten - 17

Zitat von Prometheus im Beitrag #400

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-Glycyrrhizin zur Reduzierung der UV-B-Schäden

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Zitat von Prometheus im Beitrag #400

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Kollagenpeptide

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Aging in the dermis: Fibroblast senescence and its significance
https://onlinelibrary.wiley.com/doi/full...qt1hfCqtgbQwOqI

Collagen hydrolyzate as a skin rejuvenator | The most effective dose is surprisingly low

Hydrolyzed collagen is a proven cosmeceutical. When it comes to products that keep skin young and healthy, collagen is perhaps the most thoroughly studied supplement. Moreover, according to a Japanese animal study, the effective dose is surprisingly low.

https://ergo-log.com/collagen-hydrolyzat...singly-low.html

Zitat von Tizian im Beitrag #403

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Collagen hydrolyzate as a skin rejuvenator | The most effective dose is surprisingly low

Hydrolyzed collagen is a proven cosmeceutical. When it comes to products that keep skin young and healthy, collagen is perhaps the most thoroughly studied supplement. Moreover, according to a Japanese animal study, the effective dose is surprisingly low.

https://ergo-log.com/collagen-hydrolyzat...singly-low.html

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Klingt damit eher nicht so praxistauglich.

Zitat von Methusalem im Beitrag #405

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Klingt damit eher nicht so praxistauglich.

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Zitat von Methusalem im Beitrag #405

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Klingt damit eher nicht so praxistauglich.

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Zitat von Fichtennadel im Beitrag #407

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Zitat von Methusalem im Beitrag #405

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Klingt damit eher nicht so praxistauglich.

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Äquivalenzdosis ist 1.2G pro 60kg, nicht pro 1kg falls du das meintest. Also durchaus praktikabel.

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Zur Not müsste man die Frage in einem englischsprachigen Forum stellen...

Schönen guten Morgen,
ich verwende eine Östriolcreme fürs Gesicht. Wäre diese effektiv, wenn ich ein paar Tropfen DMSO beimischen würde? es ist die Ovestin-Vaginalcreme.

Anti-aging and rejuvenating effects and mechanism of Dead Sea water in skin
https://onlinelibrary.wiley.com/doi/10.1111/ics.12931

Skin anti-aging strategies

Zitat

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In older skin, collagen looks irregular and disorganized, the ratio of Col-3, to Col-1 has been shown to increase, due, significantly, to a loss of Col-1.29 The overall collagen content per unit area of the skin surface is known to decline approximately 1%/year.30 Glycosaminoglycans (GAGs) are among the primary dermal skin matrix constituents assisting in binding water. In photo-aged skin, GAGs may be associated with abnormal elastotic material and thus be unable to function effectively.31 The total hyaluronic acid (HA) level in the dermis of skin that age intrinsically remains stable; however, epidermal HA diminishes markedly.32

Three primary structural components of the dermis, collagen, elastin and GAGs have been the subjects of the majority of anti-aging research and efforts for aesthetic-anti-aging strategies pertaining to the skin, from ”anti-wrinkle creams” to various filling agents.21

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/

Von den GAGs (Glykosaminoglykane) hatte ich noch nichts gehört, anscheinend kann man da mit Glucosamin nachhelfen.

Das Paper schreibt außerdem recht positiv über die HRT:

Zitat

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Furthermore, another study conducted by Rudman et al. has pointed out that the application of GH decreased the signs of biological aging. The treatment led to an improved body condition, with an increase of muscle mass and osseous density and a decrease of adipose tissue. Moreover, an increase of skin thickness was observed.199

(...)

HRT with testosterone is absolutely indicated in older men who are either symptomatic or have a low serum testosterone level. Either a decrease of testosterone or a loss of the circadian rhythm of testosterone secretion has been observed in a high percentage of older men. Clinical symptoms include general weakness, sexual dysfunction, diminished muscle and bone mass, and decreased erythropoiesis. A low testosterone level has been shown in epidemiological studies to lead to a higher morbidity and mortality rate and to a higher prevalence of depression, coronary heart disease, and osteoporosis. Insulin resistance has been shown to play an important role in the development of hypogonadism in older men. Thus, obese men and men with type 2 diabetes, show significantly lower testosterone levels compared with subjects in control groups.199

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Doch zurück zu Glucosamin:

Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial

Zitat

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Glucosamine sulphate (GS)
(...)
Results: Ex vivo, GS significantly (all p ≤ 0.02) increased the expression of CD44 and collagen type IV, the epidermis GAG level, and collagen type I synthesis. After 8 weeks of oral GS administration, a significantly increased expression was observed at the mRNA level for vimentin, fibromodulin, biglycan, xylosyl transferase, hyaluronan synthase, collagen types I and III, bone morphogenic protein-1, and decorin (all p ≤ 0.05).

Conclusion: Both experiments showed that GS has a positive effect on epidermal and dermal markers associated with age.

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https://pubmed.ncbi.nlm.nih.gov/28214837/

Auch Chondroitin scheint Vorteile für die Haut haben zu können - wenigstens in den Studien. Da ich von Glucosamin und Chondroitin bislang nur im Zusammenhang mit Gelenken und Knorpel gehört hatte, wirft das für mich ein neues Licht auf die beiden Stoffe.

Potential anti-ageing effect of chondroitin sulphate through skin regeneration

Zitat

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Chondroitin sulphate (CS)
(...)
Results: Chondroitin sulphate treatment increased the proliferation of keratinocytes and fibroblasts. It also stimulated the migration and synthesis of ECM components of fibroblasts. Further analysis revealed that CS induced the expression of type I procollagen by activating the extracellular signal-regulated kinase pathway. Using a full-thickness skin wound model and an aged skin model, we confirmed that CS treatment promoted skin wound healing and regeneration.

Conclusion: Together, our results indicated that CS has the potential to facilitate skin regeneration, implying that CS could be clinically applied to improve skin ageing.

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https://pubmed.ncbi.nlm.nih.gov/32583476/

Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis

Zitat

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Here, we report that chondroitin 6-sulfate is important for the maintenance of epidermal homeostasis. Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin permeability barrier function.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835381/

Was meint ihr? Habt ihr die beiden im Stack? Würdet ihr sogar HRT in Betracht ziehen?

Dill Extract Preserves Dermal Elastic Fiber Network and Functionality: Implication of Elafin
https://karger.com/spp/article-abstract/...edFrom=fulltext

Research Progress in Skin Aging and Immunity
https://www.mdpi.com/1422-0067/25/7/4101

Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils

Zitat

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Topical applications of plant oils may have different effect on the skin according to their composition and the pathophysiological context of the skin. The composition varies by different extraction methods. When applied topically, constituents of plant oils (triglycerides, phospholipids, FFAs, phenolic compounds and antioxidants) may act synergistically by several mechanisms: (i) promoting skin barrier homeostasis; (ii) antioxidative activities; (iii) anti-inflammatory properties; (iv) direct and indirect (upregulation of antimicrobial peptides) anti-microbial properties; (v) promoting wound healing; and (vi) anti-carcinogenic properties.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/

Nutzt ihr Pflanzenöle für eure Haut? Falls ja, welche? Wo seht ihr Vor- und Nachteile gegenüber konventioneller Kosmetik?

Vorteil scheint mir zu sein, dass man weiß was drin ist und leichter die Frische/Haltbarkeit überprüfen kann (olfaktorisch).
Nachteile auf jeden Fall dass es je nach Öl schlecht einziehen und man sich die Kleidung verunreinigen könnte (Fettflecken).