Verschiedenes » Ciclopirox

@Speedy

Vielen Dank für den Hinweis!

Die Daten stammen aus dieser Publikation:

FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218048/

"Ciclopirox olamine (0.01%), used to treat dermatological fungus infections, also increased maximum lifespan by 52% (Table 3) and significantly increased median lifespan (p<0.01 by Mantel-Cox log rank test; n = 45) (Figure 2A). In contrast to caffeine, ciclopirox increased lifespan even when daf-16 was inhibited by RNAi (Figure 2B) (p<0.01; n = 30). Like the other drugs tested, cbp-1 inhibition by RNAi blocked the effect of ciclopirox to increase maximum lifespan. However, unlike the other drugs in this study, the effect on median lifespan produced by ciclopirox, while reduced, was still significant (p<0.01; n = 30). Furthermore, like caffeine, ciclopirox reduced age-dependent acceleration of mortality rate (Table 2). Interestingly, inhibition of both daf-16 and cbp-1 not only blocked this protective effect but even appeared to unmask a toxic effect of ciclopirox to enhance age-related acceleration of mortality rate accompanied by a striking reduction in initial mortality rate (Table 2). A similar effect was observed for caffeine, though this did not achieve statistical significance (Table 2). In further contrast with caffeine, ciclopirox did not protect against pathology associated with proteotoxicity (Figure 2D), and in fact at the 1% concentration accelerated that pathology (not shown)."

Kommentar Prometheus:
Offensichtlich ist der Effekt von Ciclopirox UNABHÄNGIG von Kalorienrestriktion.
WICHTIG: Ciclopirox ist ausschließlich für eine topische (=äußerliche) Anwendung zugelassen! Vermutlich aus gutem Grund*

*Ich gehe davon aus, dass eine systemische antimykotische Therapiezulassung für Ciclopirox wegen Toxizität oder Unwirksamkeit gescheitert ist.
Ob in "homöopathischen" Dosierungen der bei C.elegans beschriebene Effekt auch beim Menschen erzielt werden könnte, ist derzeit rein spekulativ.