Verschiedenes » Methan

Es ist überaschend wie viele positive Wirkungen Methan hat!
Antioxidativ, Anti-inflammatorisch, Anti-proliferative, sowie Anti-apoptotische Wirkungen konnten bereits gezeigt werden.

In dem Sinne muss man sagen, mehr Mut zu blähenden Lebensmitteln wie Hülsenfrüchten, Zwiebeln usw.
Vermutlich rührt auch ein Teil der Wirkung von ballaststoffreichen Pflanzen und einer vielfälltigen Darmflora vom Methan.

Da auch eingeatmetes Methan vorteilhaft zu wirken scheint, könnte auch ein Wohnort oder Kuraufenthalt an Mooren/Sümpfen eine Wirkung haben, da die Mikroorganismen dort, genau wie in unserem Verdauungstrakt, in den sauerstoffarmen Zonen Methan freisetzen.

Methane-rich saline protects against sepsis-associated cognitive deficits in mice
Highlight:
•Sepsis causes sepsis-associated encephalopathy.
•Methane has antiinflammatory and antioxidative effects.
•Methane alleviates sepsis-induced cognitive deficits in mice.

Abstract:

Zitat

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Sepsis is associated with multiple organ dysfunction, and the brain is particularly vulnerable. Sepsis-associated encephalopathy (SAE) increases the mortality of patients with sepsis; however, the pathogenesis of SAE remains unclear. Methane, the simplest aliphatic hydrocarbon, has been reported to have anti-inflammatory and organ-protective effects. This study aimed to investigate the effects of methane on the cognitive deficits in mice with experimental sepsis. We randomly divided C57BL/6 male mice into sham, cecal ligation and puncture (CLP), and CLP + methane-rich saline (MS) groups. Twenty-four hours after surgery, behavioral tests were conducted on surviving mice and the hippocampus were collected for biochemical analysis. We found that CLP resulted in cognitive deficits in septic mice. A physiological mechanistic investigation revealed that microglia in the hippocampus are largely activated, coupled with the production of inflammatory cytokines and reactive oxygen species (ROS). Notably, methane inhibited the activation of microglia in the hippocampus, reduced the severity of inflammation, diminished the generation of ROS, and ultimately alleviated behavioral impairment in septic mice. Together, these show that treatment with methane ameliorated cognitive deficits in septic mice, which is partly related to the anti-inflammatory and antioxidative effects in the hippocampus.

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https://www.sciencedirect.com/science/ar...006899322002244

The anti-inflammatory effects of methane
Abstract:

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Objective: Gastrointestinal methane generation has been demonstrated in various stress conditions, but it is not known whether nonasphyxiating amounts have any impact on the mammalian pathophysiology. We set out to characterize the effects of exogenous methane administration on the process of inflammatory events arising after reoxygenation in a large animal model of ischemia-reperfusion.

Design: A randomized, controlled in vivo animal study.

Setting: A university research laboratory.

Subjects: Inbred beagle dogs (12.7 6 2 kg).

Interventions: Sodium pentobarbital-anesthetized animals were randomly assigned to sham-operated or ischemia-reperfusion groups, where superior mesenteric artery occlusion was maintained for 1 hr and the subsequent reperfusion was monitored for 3 hrs. For 5 mins before reperfusion, the animals were mechanically ventilated with normoxic artificial air with or without 2.5% methane. Biological responses to methane-oxygen respirations were defined in pilot rat studies and assay systems were used with xanthine oxidase and activated canine granulocytes to test the in vitro bioactivity potential of different gas concentrations.

Measurements and main results: The macrohemodynamics and small intestinal pCO(2) gap changes were recorded and peripheral blood samples were taken for plasma nitrite/nitrate and myeloperoxidase analyses. Tissue superoxide and nitrotyrosine levels and myeloperoxidase activity changes were determined in intestinal biopsy samples; structural mucosal damage was measured by hematoxylin and eosin staining. Methane inhalation did not influence the macrohemodynamics but significantly reduced the magnitude of the tissue damage and the intestinal pCO(2) gap changes after reperfusion. Furthermore, the plasma and mucosal myeloperoxidase activity and the intestinal superoxide and nitrotyrosine levels were reduced, whereas the plasma nitrite/nitrate concentrations were increased. Additionally, methane effectively and specifically inhibited leukocyte activation in vitro.

Conclusions: These data demonstrate the anti-inflammatory profile of methane. The study provides evidence that exogenous methane modulates leukocyte activation and affects key events of ischemia-reperfusion-induced oxidative and nitrosative stress and is therefore of potential therapeutic interest in inflammatory pathologies.

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https://pubmed.ncbi.nlm.nih.gov/22336723/

Methane and Inflammation - A Review (Fight Fire with Fire)
Abstract:

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Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.

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https://pubmed.ncbi.nlm.nih.gov/31807906/

Therapeutic effect of methane and its mechanism in disease treatment
Abstract:

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Methane is the simplest hydrocarbon, consisting of one carbon atom and four hydrogen atoms. It is abundant in marsh gas, livestock rumination, and combustible ice. Little is known about the use of methane in human disease treatment. Current research indicates that methane is useful for treating several diseases including ischemia and reperfusion injury, and inflammatory diseases. The mechanisms underlying the protective effects of methane appear primarily to involve anti-oxidation, anti-inflammation, and anti-apoptosis. In this review, we describe the beneficial effects of methane on different diseases, summarize possible mechanisms by which methane may act in these conditions, and discuss the purpose of methane production in hypoxic conditions. Then we propose several promising directions for the future research.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445089/

Methane Medicine: A Rising Star Gas with Powerful Anti-Inflammation, Antioxidant, and Antiapoptosis Properties
Abstract:

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Methane, the simplest organic compound, was deemed to have little physiological action for decades. However, recently, many basic studies have discovered that methane has several important biological effects that can protect cells and organs from inflammation, oxidant, and apoptosis. Heretofore, there are two delivery methods that have been applied to researches and have been proved to be feasible, including the inhalation of methane gas and injection with the methane-rich saline. This review studies on the clinical development of methane and discusses about the mechanism behind these protective effects. As a new field in gas medicine, this study also comes up with some problems and prospects on methane and further studies.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878870/

Ich bin ja ein Anhänger von Isotopenwirkungen! @Licht ist da ja der Experte von alternativen Theorien.
Mein Gedankengang ist immer noch, das Wasserstoff-Gas oder auch Methane böses Deuterium aufnimmt und aus dem Körper leitet. Glaube die Theorie der Studien sagt, Wasserstoff oder Methan lagert sich an an Enzyme und beeinflusst sie. Die meisten Moleküle berühren sich ja nur am Wasserstoff.
https://en.m.wikipedia.org/wiki/Methane_clumped_isotopes
https://pubmed.ncbi.nlm.nih.gov/25745067/
We demonstrate quantitatively that H2 availability accounts for this effect.
Darum vielleicht die ähnlichen Wirkungen?

Wäre interessant welche Isotopenzusammensetzung für die Studien verwendet wurden.