vielen lieben Dank für die Verlinkung dieses Buches! Ich habe mir bereits einige Anregungen geholt. Ich denke ich werde meine bisherige Methode (Vegan an Werktagen) ein wenig abwandeln und tendentiell lieber kürzer, dafür aber konsequenter auf Protein verzichten:
ZitatThe final question is how often should protein restriction be practiced. The answer to that is a little more involved.
First we must consider what the purpose of promoting autophagy is. It is to clear the cell of degraded and aggregated proteins that are not being handled by the other recycling mechanisms of the cell. To prevent the accumulation we must clear them at a least the same rate as they are produced. We do not really know the production rate of these aggregates but we can infer them from the known usual courses of the diseases we are trying to forestall.
We can calculate the rate of clearing by autophagy from certain known values. We know a 70,000g (154lb) male requires about 25g of protein per day to meet his own protein synthesis needs. Perhaps the body conserves a bit when protein is restricted so, to be conservative as well, we will say 20g of protein is the minimum. We know that cell contents account for about 2/3 of body weight*. We know that the body is about 17% protein and 17% fat by weight. 70,000g x 17% x 2/3 = 8000g of cell protein. When autophagy is induced by protein starvation, at least 20g per day of protein must then be recycled. 20g/8000g = 0.25% per day recycled. As long as that value exceeds the rate of accumulation of aggregates, a neurodegenerative disease produced by those aggregates can in theory be prevented.
Im Prinzip überschneidet sich das Thread ja teilweise mit dem Thread Methioninrestriktion. Proteinzyklieren ist eine Form von Hormesis und dient letztlich einer Verbesserung der Autophagie.
Hier ist übrigens die Empfehlung von Ron Mignery (aus #1):
ZitatFrom the table we can see that 3 days a week of protein restriction would be sufficient to counteract an exponential accumulation that doubles every 2.5 years. This then is my most recommended regime: three 24 hour periods each week where very little protein is consumed.