RE: Spermidin - 5

The positive effect of spermidine in older adults suffering from dementia after 1 year
https://link.springer.com/article/10.1007/s00508-023-02226-z

Spermidine improves the antioxidant capacity and morphology of intestinal tissues and regulates intestinal microorganisms in Sichuan white geese

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Our results showed that spermidine could increase the ratio of intestinal villus to crypt and improve intestinal morphology. In addition, spermidine can also reduce malondialdehyde (MDA) accumulation caused by 3-NPA by increasing superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activity, thus alleviating intestinal damage. Furthermore, spermidine can regulate intestinal digestive enzyme activities and affect intestinal digestion and absorption ability. Spermidine can also promote an increase in intestinal microbial diversity and abundance and alleviate the change of microflora structure caused by 3-NPA. In conclusion, spermidine promotes the production of beneficial intestinal metabolites such as Wikstromol, Alpha-bisabolol and AS 1–5, thus improving the level of intestinal health. Taken together, these results indicate that spermidine can improve intestinal health by improving intestinal morphology, increasing antioxidant capacity and regulating intestinal flora structure.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824853/

Spermidine ameliorates osteoarthritis via altering macrophage polarization

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Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through anti-apoptosis and anti-inflammation. However, the specific protective mechanism of SPD in osteoarthritis (OA) remains unclear. Here, we explored the role of SPD on the articular cartilage and the synovial tissue, and tested whether the drug would regulate the polarization of synovial macrophages by in vivo and in vitro experiments.
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This work provides new perspectives on the role of SPD in OA. SPD does not directly target chondrocytes, but can ameliorate the degradation of articular cartilage through regulating M1/M2 polarization of synovial macrophages. Hence, SPD is expected to be the potential therapy for OA.

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https://pubmed.ncbi.nlm.nih.gov/38367900/

Spermidine - an old molecule with a new age-defying immune function

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We highlight the effectiveness of spermidine in enhancing antitumor responses in aged animals otherwise nonresponsive to immune checkpoint therapy and propose that spermidine supplementation could be used to enhance the efficacy of anti-PD-1 treatment.

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https://pubmed.ncbi.nlm.nih.gov/37723019/

Gibt es denn inzwischen irgendwo reines Spermidin zu kaufen? Sehr komisch, dass man nur Extrakte mit vergleichsweise niedrigem Gehalt an Spermidin findet.

Zitat von version2 im Beitrag #101

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Gibt es denn inzwischen irgendwo reines Spermidin zu kaufen? Sehr komisch, dass man nur Extrakte mit vergleichsweise niedrigem Gehalt an Spermidin findet.

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