RE: Aspirin - 3

Warum sollte man kein Aspirin oder Ibuprofen nehmen, wenn man Schmerzen hat? Die Leute die Babyaspirin nehmen müssen, sind meist doch krank und ich sehen nicht jugendlich aus. Es wirkt auf mich halt von dem her nicht sexy. Ich habe es mal einige Monate genommen, naja hätte eine höhere Neigung zu blauen Flecken. Ich nehme jetzt ab und zu Weidenrindenpulver vom DM-Markt, aber man kann keine Verjüngung sehen ;)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840773/



Neurodegenerative disorders such as Alzheimers disease (AD) are multifaceted and there are currently a limited number of therapeutic strategies available to treat them. Aspirin is known to act on multiple therapeutic targets and is a successful anti-inflammatory agent in various tissues. The present study aimed to ascertain the performance of aspirin when employed as a therapeutic agent to treat neurodegeneration on novel targets, including opioid system genes, in an AlCl3-induced neurotoxicity mouse model. The effects of two doses of aspirin (5 and 20 mg/kg aspirin for 12 days) were investigated in an AlCl3-induced neurotoxicity mouse model (150 mg/kg AlCl3 for 12 days). Neurological improvements were assessed through different behavioral tests and the effects of aspirin on opioid system gene expression levels were assessed by reverse transcription-polymerase chain reaction. Both doses resulted in improvements in cognitive behavior. A 5 mg/kg dose of aspirin was revealed to be effective for spatial memory improvement (7.14±0.84 sec), whilst a 20 mg/kg dose was superior for improving extinction learning (7.63±4.04%). Aspirin (5 mg/kg) also significantly improved contextual memory (48.05±10.6%) when compared with the AlCl3-treated group (1.49±0.62%; P<0.001). Aspirin was also observed to significantly decrease δ-opioid receptor expression in the cortex (1.09±0.08 and 1.27±0.08, respectively) at both doses (5 and 20 mg/kg) when compared with the AlCl3-treated group (3.69±1.43; P<0.05). Furthermore, aspirin at 5 mg/kg significantly reduced expression of prodynorphin in the cortex (0.57±0.20) when compared with the AlCl3-treated group (1.95±0.84; P<0.05). Notably, the effect of aspirin was significant in the cortex but not in the hippocampus. In summary, aspirin was effective in ameliorating the AD-like symptoms via the modulation of opioid systems. However, additional studies are required to determine the long term effects of aspirin on such conditions.

Zitat

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Aspirin gilt als Tausendsassa unter den Medikamenten: Das Mittel wirkt schmerzstillend, fiebersenkend, blutverdünnend - und hilft sogar bei erhöhten Cholesterinwerten. Forscher haben nun untersucht, wie genau der Wirkstoff Acetylsalicylsäure in diesem Zusammenhang seine Wirkung entfaltet. Demnach löst das Mittel Ansammlungen von Cholesterin in der Zellmembran auf, die sich dort typischerweise bei hohen Cholesterinkonzentrationen bilden.

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http://www.scinexx.de/wissen-aktuell-22472-2018-02-28.html

Ich habe eine Zeit lang Aspirin 100 Protect genommen, da ich vor Jahren eine Thrombose hatte. Ich bekam leichter blaue Flecken.
Nach Recherche bin ich auf Curcumin, Kurkuma Kapseln und Kurkumawasser umgestiegen. Das hat auch eine blutverdünnende und stark entzündungshemmende Wirkung. Dabei bin ich geblieben.
Was macht ihr?

@Aika100
ein Freund von mir, der einige Tias hatte, ist von Aspirin zu OPC gewechselt und kommt damit auch sehr gut hin.
Liebe Grüße von Julie

Das Blutungsrisiko soll bei zusätzlicher Einnahme von Vitamin K2 MK-4! deutlich gesenkt werden können.

Daily aspirin linked to double melanoma risk in men
https://www.sciencedaily.com/releases/20...80503142628.htm

Zitat: "For the aspirin-exposed patient population, the study included only patients who had at least one year of once-daily aspirin exposure at a dose of 81 or 325 mg ccurring between January 2005 and December 2006 in order to allow for at least five years of follow-up data to detect if melanoma occurred over time."

Irgend einen Link einzustellen ohne Interpretation, ist nicht gut. Das verwirrt nur.

Wenn die Autoren zwei unterschiedliche Dosierungen in einen Topf schmeißen, ist die Studie nicht brauchbar. Die positiven Effekte wurden bisher für Dosierungen zwischen 81 und 100 mg ermittelt und gerade nicht für höhere Dosierungen.
Ich kenne die Studie nicht im Einzelnen. Oder gibt es noch andere Erkenntnisse?

Oder ganz unwissenschaftlich...
Vielleicht sind gesunde Menschen insgesamt robuster auch gegen Hautkrebs.
Die Leute die Babyaspirin nehmen müssen, haben ja meist Herzprobleme.
Meine These ist, durch die schlechtere Blutversorgung (der Haut) mit der entzündungshemmenden Wirkung des Aspirins, führt zu verzögerten Reperaturen der geschädigten Haut und das Entartungsrisiko steigt.

Ohne Gewähr und ganz unwissenschaflich

Also ich habe auch Mini-Aspirin in der kleinstmöglichen Dosis rumliegen (75 mg). Davon würde ich dauerhaft höchstens eine halbe nehmen, falls mir nicht anderes zur Verfügung stünde.

Trotzdem bin ich ein Gegner regelmäßiger Aspirineinnahme.

Im Prinzip kann m.Mng. nach Aspirin nichts, was andere nicht besser können. Vitamin K, Magnesium, Piracetam, Curcuma, das alles sind bessere Mittel für die verschiedenen Beschwerden. Diese haben auch weniger Nebenwirkungen. Warum also sollte ich Aspirin einnehmen, wenn es bessere Substanzen mit weniger Nebenwirkungen gibt.

Aspirin fördert die Schwerhörigkeit. Magnesium und Piracetam verhindern sie nicht nur, sondern verbessern sogar teilweise das Hörvermögen.

Vitamin K verbessert nicht nur Blutgefäße, sondern auch die Zähne und die Knochen...

Curcuma hemmt COX-2 (Entzündungen), ohne den Magen kaputtzumachen.

Wir haben einfach bessere Alternativen als Aspirin und brauchen das gar nicht bzw. höchstens als Notfallmedikament.

Zitat von Wolfgang aus Berlin im Beitrag #59

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Zitat: "For the aspirin-exposed patient population, the study included only patients who had at least one year of once-daily aspirin exposure at a dose of 81 or 325 mg ccurring between January 2005 and December 2006 in order to allow for at least five years of follow-up data to detect if melanoma occurred over time."

Irgend einen Link einzustellen ohne Interpretation, ist nicht gut. Das verwirrt nur.

Wenn die Autoren zwei unterschiedliche Dosierungen in einen Topf schmeißen, ist die Studie nicht brauchbar. Die positiven Effekte wurden bisher für Dosierungen zwischen 81 und 100 mg ermittelt und gerade nicht für höhere Dosierungen.
Ich kenne die Studie nicht im Einzelnen. Oder gibt es noch andere Erkenntnisse?

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Aspirin hilft bei Alzheimer
Plaques lösen sich auf
Eine Kur mit niedrig dosiertem Aspirin löst möglicherweise Plaques im Gehirn auf, die die Alzheimer-Krankheit auslösen. Das ist das Ergebnis der Studie eines Teams um die Neurologen Professor Floyd A. Davis und Kalipada Pahan vom Rush University Medical Center http://rushu.rush.edu . "Die Ergebnisse unserer Studie zeigen, dass eines der meist genutzten rezeptfreien Medikamente eine weitere Rolle spielen könnte", sagt Pahan.

Zitat

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Kleinere Plaques nach einem Monat Die Forscher konnten bei Versuchen an Mäusen zeigen, dass Aspirin Lysosome aktivieren, die Biopolymere in Monomere zerlegen. Diese bilden sich aus dem Protein TFEB. Sie sind für die "Reinigung" des Gehirns zuständig. Die an Alzheimer künstlich erkrankten Mäuse erhielten einen Monat lang Aspirin. Danach hatten sich die Plaques deutlich verkleinert.

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https://www.wallstreet-online.de/nachric...-plaques-loesen





Aspirin hilft bei Alzheimer: Plaques lösen sich auf
Erste Tests mit Mäusen erfolgreich - Neue Hoffnung für Demenzkranke
https://www.pressetext.com/news/20180704002

https://www.ncbi.nlm.nih.gov/pubmed/30187283

Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.

Increasing the function of residual dopaminergic neurons in the nigra of PD patients is an important area of research as it may eventually compensate the loss. Although tyrosine hydroxylase (TH) is the rate-limiting enzyme in the dopamine (DA) biosynthesis pathway, there are no effective drugs/molecules to upregulate TH and increase the production of DA in nigral dopaminergic neurons. This study underlines the importance of aspirin in stimulating the expression of TH and increasing the level of DA in dopaminergic neurons. At low doses, aspirin increased the expression of TH and the production of DA in mouse MN9D dopaminergic neuronal cells. Accordingly, oral administration of aspirin increased the expression of TH in the nigra and upregulated the level of DA in striatum of normal C57/BL6 mice and aged A53T α-syn transgenic mice. Oral aspirin also improved locomotor activities of normal mice and A53T transgenic mice. While investigating mechanisms, we found the presence of cAMP response element (CRE) in the promoter of TH gene and the rapid induction of cAMP response element binding (CREB) activation by aspirin in dopaminergic neuronal cells. Aspirin treatment also increased the level of phospho-CREB in the nigra of C57/BL6 mice. The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB. These results highlight a new property of aspirin in stimulating the TH-DA pathway, which may be beneficial in PD patients. Graphical Abstract ᅟ.

Aspirin in geringen Dosen scheint scheint MS-Symptome zu lindern, Schübe zu verhindern und evtl. sogar die Degeneration "zurückzuschrauben"


http://stke.sciencemag.org/content/11/558/eaar8278


Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11–mediated protection of regulatory T cells

"...We observed marked expression of proinflammatory molecules like iNOS and IL-1 in spinal cord tissue from untreated RR-EAE mice when compared to control mice (fig. S1A and Fig. 2, D and E). However, aspirin treatment markedly suppressed the mRNA expression of iNOS and IL-1 in spinal cord tissue from mice with RR-EAE (fig. S1A and Fig. 2, D and E)."

"...Additionally, recombinant human IL-11 markedly suppresses bacterial lipopolysaccharide-induced NO production from macrophages (35). Therefore, it is possible that IL-11 prevented conversion of Tregs in EAE mice by suppressing the production of NO."

"...Here, we describe a new function of aspirin in which this drug inhibits the autoimmune disease EAE. Oral use of low-dose aspirin reduced the progression of both adoptively transferred and chronic EAE in mice. Aspirin treatment of mice with EAE also inhibited the invasion of mononuclear cells into the spinal cord as well as the expression of inflammatory molecules [inducible nitric oxide synthase (iNOS) and IL-1] and restored myelination and the expression of myelin-specific genes within the CNS. A recent double-blind randomized controlled pilot trial suggests that aspirin may represent an effective pretreatment for exercise in MS (29). Fatigue is very common in MS, and low-dose aspirin is also being considered for treating MS-related fatigues (30). Here, our preclinical data suggest that low-dose aspirin may be repurposed for disease modification in MS patients.

"...Although at high doses aspirin is reported to exhibit some toxic effects (gastric ulcers, stomach bleeding, tinnitus, etc.) (38), in our study aspirin suppressed the disease process of EAE at low doses (1 and 2 mg/kg body weight per day). A single pill of baby aspirin containing 81 mg of aspirin is considered to be very much safe for adults for daily use, and the doses we used in mice are almost equivalent to baby aspirin."

Lose-dose aspirin may help fight MS, study with mice says
"...Although the findings are so far only in mice, studies suggest that aspirin -- even the "low-dose" variety -- might help counter multiple sclerosis. Multiple sclerosis, or MS, is an autoimmune disorder where aberrant immune system T-cells attack and destroy the protective myelin protein sheath that coats nerves."

"...For the study, Mondal's team fed aspirin to mice specially bred to mimic the human form of MS. The investigators found that even low doses of aspirin -- equal to the 81 milligram "baby aspirin" many take to ward off heart trouble -- seemed to curb symptoms of MS in the mice. What's more, the pain reliever seemed to push back the underlying disease itself. "

"..."Although mouse results are not always translated to humans, our results highlight an undiscovered property of aspirin and suggest that low-dose aspirin may be repurposed for therapeutic intervention in MS," the study team wrote."

Aspirin, kann über Resolvine, die Hämoxygenase-1 aktivieren, was den Antioxidativen Schutz in Zellen hochfährt und die Auflösung von Entzündungen antreibt:

Heme oxygenase-1 induction may explain the antioxidant profile of aspirin
https://www.sciencedirect.com/science/ar...5043?via%3Dihub


Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells
https://www.physiology.org/doi/full/10.1...cr_pub%3Dpubmed

Siehe dazu auch:Chronische Entzündungen, ganz allgemein

Aspirin protektiv bei Luftverschmutzung:




https://www.studyfinds.org/aspirin-may-p...-air-pollution/

https://raypeatforum.com/community/threa...ollution.31175/

https://www.eurekalert.org/pub_releases/...p-cad102319.php

Researchers conducted a database search to investigate whether aspirin can aid in the prevention of intracranial aneurysm rupture by hindering aneurysm growth. The researchers identified 146 patients harboring multiple intracranial aneurysms, five millimeters or less in diameter, that had been observed for at least five years. In this set of patients, the researchers found an association between aspirin use and a decreased rate of aneurysm growth. Growth is important in intracranial aneurysms because it increases the risk of aneurysm rupture. Detailed findings are found in the article, "Aspirin associated with decreased rate of intracranial aneurysm growth," by Mario Zanaty, M.D., and colleagues, published today in the Journal of Neurosurgery.


https://thejns.org/view/journals/j-neuro...6.JNS191273.xml


RESULTS

The authors identified 146 patients harboring a total of 375 IAs. At the initial encounter, 146 aneurysms were treated and the remaining 229 aneurysms (2–5 mm) were observed. During the follow-up period, 24 (10.48%) of 229 aneurysms grew. All aneurysms observed to grow later underwent treatment. None of the observed aneurysms ruptured. Multivariate analysis showed that aspirin was significantly associated with a decreased rate of growth (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.05–0.63). Variables associated with an increased rate of growth included hypertension (OR 14.38, 95% CI 3.83–53.94), drug abuse (OR 11.26, 95% CI 1.21–104.65), history of polycystic kidney disease (OR 9.48, 95% CI 1.51–59.35), and subarachnoid hemorrhage at presentation (OR 5.91, 95% CI 1.83–19.09).

CONCLUSIONS

In patients with multiple IAs, aspirin significantly decreased the rate of aneurysm growth over time. Additional prospective interventional studies are needed to validate these findings.

Effect of low‐dose aspirin on health outcomes: An umbrella review of systematic reviews and meta‐analyses
https://bpspubs.onlinelibrary.wiley.com/...OsLPOUnNiepXPo4

https://www.sciencedaily.com/releases/20...01022195637.htm


Hospitalized COVID-19 patients who were taking a daily low-dose aspirin to protect against cardiovascular disease had a significantly lower risk of complications and death compared to those who were not taking aspirin, according to a new study led by researchers at the University of Maryland School of Medicine (UMSOM).
Aspirin takers were less likely to be placed in the intensive care unit (ICU) or hooked up to a mechanical ventilator, and they were more likely to survive the infection compared to hospitalized patients who were not taking aspirin, The study, published today in the journal Anesthesia and Analgesia, provides "cautious optimism," the researchers say, for an inexpensive, accessible medication with a well-known safety profile that could help prevent severe complications.

"This is a critical finding that needs to be confirmed through a randomized clinical trial," said study leader Jonathan Chow, MD, Assistant Professor of Anesthesiology at UMSOM. "If our finding is confirmed, it would make aspirin the first widely available, over-the-counter medication to reduce mortality in COVID-19 patients."

To conduct the study, Dr. Chow and his colleagues culled through the medical records of 412 COVID-19 patients, age of 55 on average, who were hospitalized over the past few months due to complications of their infection. They were treated at the University of Maryland Medical Center in Baltimore and three other hospitals along the East Coast. About a quarter of the patients were taking a daily low-dose aspirin (usually 81 milligrams) before they were admitted or right after admission to manage their cardiovascular disease.

The researchers found aspirin use was associated with a 44 percent reduction in the risk of being put on a mechanical ventilator, a 43 percent decrease in the risk of ICU admission and -- most importantly -- a 47 percent decrease in the risk of dying in the hospital compared to those who were not taking aspirin. The patients in the aspirin group did not experience a significant increase in adverse events such as major bleeding while hospitalized.

Wurde die hier eigtl. mal gepostet: Aspirin ist Metformin überlegen was Verlängerung Lifespan und Healthspan angeht, ganz ohne metabolische Trade-Off-Effekte wie sie Metformin induzieren.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382469/

Zitat von Fichtennadel im Beitrag #71

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Wurde die hier eigtl. mal gepostet: Aspirin ist Metformin überlegen was Verlängerung Lifespan und Healthspan angeht, ganz ohne metabolische Trade-Off-Effekte wie sie Metformin induzieren.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382469/

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Hallo Speedy,

bis vor einigen Jahren habe ich die Aspirin 100 mg Tabletten halbiert (50 mg sind entsprechend der Empfehlung von Dr. Kuklinski wahrscheinlich "ungefährlich") und später habe ich Aspirin durch Ginkgo ersetzt.

Viele Grüße

Roger

leider gibt es immer wieder Menschen, ...
die es (auch in pflanzlicher Form) nicht vertragen, ...
Glück haben, ...
und es bemerken ...

(innere Blutungen ...
können sehr unter-schwellig auf-treten) ...

[

Zitat von Roger im Beitrag #73

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Hallo Speedy,

bis vor einigen Jahren habe ich die Aspirin 100 mg Tabletten halbiert (50 mg sind entsprechend der Empfehlung von Dr. Kuklinski wahrscheinlich "ungefährlich") und später habe ich Aspirin durch Ginkgo ersetzt.

Viele Grüße

Roger

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