Nahrungsergänzung » Senegenin

Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia
https://www.frontiersin.org/articles/10....022.937333/full

Polygala Tenuifolia

Zitat

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Polygala Tenuifolia is one of the most frequently mentioned herbs in the Zhong Hua Yi Dian (“Encyclopedia of Traditional Chinese Medicine“) for memory disorders and improvement.[xi]

Polygala Tenuifolia acts as an MOA inhibitor which increases dopamine and norepinephrine in your brain.

This ancient Chinese herb helps reduce cortisol, inhibits inflammation, and regulates glutamate AMPA receptors.

Polygala Tenuifolia extract has been shown to reduce the proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-8 levels in the hippocampus. Which has been shown in animal studies to have a significant effects on learning and memory.

Polygala Tenuifolia boosts the expression of brain-derived neurotrophic factor (BDNF) and Nerve Growth Factor (NGF), increase synaptic plasticity, and decrease the accumulation of amyloid β-protein implicated in Alzheimer’s Disease.

It has also been found to increase dopamine neurons and improve motor impairment in Parkinson’s Disease.[xii]

Neurohackers consistently report Polygala Tenuifolia is a potent anxiolytic and reduces anxiety quickly especially when used sublingually.

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https://nootropicsexpert.com/polygala-tenuifolia/

Senegenin ist eher für den Schlaf?

Zitat

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The active component found in Polygala Tenuifolia that provides it sedative effective is Senegenin.

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Tenuifolin (Polygala tenuifolia) ameliorates corticosterone-induced endoplasmic reticulum stress and mitochondrial dyshomeostasis by reprogramming CLOCK in PC12 cells
https://www.sciencedirect.com/science/ar...212429225000276