Nahrungsergänzung » Theanin

Theanin, genauer L-Theanin ist eine Aminosäure, die bspw. in Grünem Tee vorkommt.

L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans

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L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effects, regulation of the immune response, relaxing neural tension, and reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also upregulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provides a theoretical basis for the possibility that tea drinking may prevent mitochondrial-related diseases.

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https://www.mdpi.com/1420-3049/29/11/2691

Synergistic effects of epigallocatechin gallate and l-theanine in nerve repair and regeneration by anti-amyloid damage, promoting metabolism, and nourishing nerve cells

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This study demonstrates that EGCG and L-theanine synergistically promote repair and regeneration of differentiated neural cell line PC12 cells under amyloid stress conditions. EGCG mainly inhibits amyloid stress and inflammation and promotes lipid metabolism. In the presence of EGCG, L-theanine can fully exert its neurotrophic effect. EGCG + L-theanine targets the cell cycle, keeps nerve cells in a quiescent state under amyloid stress, promotes cell viability and axonal growth, and maintains the high-fidelity structure of cellular proteins.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399931/

Theanin gegen Cadmium:

Protective Effect of L-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway
https://pubmed.ncbi.nlm.nih.gov/26164708/

Theanin und das Immunsystem, gerade auch bei sportlich aktiven Menschen:

L-Theanine and Immunity: A Review

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Compared with its sedative and calming activities, the immunomodulatory effects of L-theanine have received less attention. Clinical and epidemiological studies have shown that L-theanine reduces immunosuppression caused by strenuous exercise and prevents colds and influenza by improving immunity. Numerous cell and animal studies have proven that theanine plays an immunoregulatory role in inflammation, nerve damage, the intestinal tract, and tumors by regulating γδT lymphocyte function, glutathione (GSH) synthesis, and the secretion of cytokines and neurotransmitters. In addition, theanine can be used as an immunomodulator in animal production.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179891/

Dazu, wie viel Theanin nun in einer Tasse Tee steckt, gibt es unterschiedliche Ergebnisse:

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A regular cup of green tea naturally contains about 25 mg of L-theanine.

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https://www.supplysidesj.com/supplements...e-of-l-theanine-

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Contrary to previous research, a standard (200 ml) cup of black tea was found to contain the most l-theanine (24.2 ± 5.7 mg) while a cup of green tea contained the least (7.9 ± 3.8 mg).

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https://www.sciencedirect.com/science/ar...308814610011416

Für die Mitochondrien schon interessant. Die Synergieeffekte mit EGCG ebenfalls. Gibt es eigentlich überhaupt Gründe, die gegen L-Theanin sprechen?

https://www.orthoknowledge.eu/neuigkeite...en-depressionen

L-Theanin wirksam bei schweren Depressionen

Hallo,

Theanin unterstützt u.a. die Stressreduktion (siehe auch Link).

Viele Grüße

Roger