Bewegung und Sport » Myokine, hier: Sport und Irisin

Irisin- ein wunderbares Myokin, also ein vom Muskel ausgeschütteter Stoff- und Muskeln hat man oder hat man nicht...Beim Menschen steigt weiterhin der Irisin-Spiegel nach zehn Wochen regelmäßiger körperlicher Aktivität auf das Doppelte des Baselevels.

Hier verglich man Hundertjährige mit gesunden 27-39jährigen und einer ebenso alten Vergleichsgruppe mit frischem Herzinfarkt



Conclusion
"Our study demonstrates that healthy centenarians are characterized by increased serum irisin levels, whereas levels of this molecule were found to be significantly lower in young patients with myocardial infarction", the Spanish researchers wrote. "Altogether, our data indicate that circulating irisin levels may be significantly associated with successful aging and could serve as a potential vascular risk marker...

"However, further mechanistic studies are required to investigate whether irisin could act as a protective factor for the development of cardiovascular disease and age-related disorders. We speculate that the high irisin levels observed in our centenarians may reflect successful aging because this sample was actually disease free."




http://www.ncbi.nlm.nih.gov/pubmed/24813865

Und vor Krebs schützt es nebenbei auch noch:
http://www.ncbi.nlm.nih.gov/pubmed/25124080

Zitat von Prometheus im Beitrag #2

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Inkretinmimetikum Exenatid - das ist ein Medikament, dass bei Diabetes mellitus angewendet wird):

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Plasma irisin levels predict telomere length in healthy adults

Zitat

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Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure.
(...)
Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (...) and plasma irisin levels (...). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039281/

Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase

Zitat

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In conclusion, irisin is a key player during the ageing process and it could be a novel target molecule for the therapeutic approach to boost longevity pathways.

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https://www.cambridge.org/core/journals/...B15E4677A5D7213

Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Zitat

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Irisin affects blood pressure and controls hypertension through modulating vasodilatation. Moreover, irisin can enhance vasoconstriction via the hypothalamus. Because of these dual effects of irisin on cardiovascular physiology, irisin can be a critical therapeutic target in cardiovascular diseases.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392379/

Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction

Zitat

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We then delivered recombinant irisin protein intraperitoneally into ageing or aged mice and found that it could improve sarcopenia with grip strength (+18.42%, P < 0.01 or +13.88%, P < 0.01), muscle weights (QU: +9.02%, P < 0.01 or +16.39%, P < 0.05), fibre size (QU: both P < 0.05) and molecular phenotypes and alleviated age‐associated fat tissues expansion, insulin resistance and hepatic steatosis (all P < 0.05), accompanied with altered gene signatures.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891925/

Pinealon soll ja Irisin regulieren können:

Short Peptides and Telomere Length Regulator Hormone Irisin

Zitat

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The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.

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https://pubmed.ncbi.nlm.nih.gov/26742748/

Das wäre vielleicht ein anderer Pfad zur Telomerverlängerung.

Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology
https://www.mdpi.com/1422-0067/25/24/13480