Exploring the Potential Hepatoprotective Properties of Cactus (Cactaceae) in Liver Health and Disease Management: A Brief Review https://www.mdpi.com/2673-4389/4/2/21
Synbiotics are supplements that contain dietary fibers such as inulin and benign bacteria such as Streptococcus thermophilus. If you give such a synbiotic supplement to someone with a fatty liver, he will become healthier. The concentration of liver enzymes and LDL will decrease, sensitivity to insulin will increase and the concentration of TNF-alpha will decrease.
SIRT3, a New Hope in Liver Diseases from Pathogenic Mechanisms to Therapeutic Strategies
ZitatThe liver, the largest internal organ in the human body, regulates multiple reactions and processes, including detoxification, regeneration, and immune defense. Liver diseases have emerged as a significant global public health issue. Numerous studies have indicated that the mitochondrial deacetylase SIRT3 has played various roles in the pathogenesis and pathological progression of liver diseases. Objectives: This review aims to explore the advances in the study of SIRT3 and liver disease and review possible mechanisms. Natural and chemical activators of SIRT3 are also discussed. The role of SIRT3 in the pathogenic mechanisms and therapeutic strategies of liver disease is summarized by reviewing Pubmed. SIRT3 alleviates liver diseases by regulating fatty acid metabolism, mitochondrial function, and immune-inflammatory response. Meanwhile, Withaferin A, lipoic acid, major royal jelly proteins, and berberine can activate SIRT3 or upregulate its expression, thereby alleviating liver damage. SIRT3 can effectively slow down the progression of liver disease and protect the liver from further damage. The use of SIRT3 as a pharmacological target for the treatment of liver disease is a potential therapeutic approach.