Reducing work stress is activating NK cells For the innate immune system, the first immunological line of defense against cancer and pathogens, stress is just as important a factor as sleep and physical activity. We reviewed two human studies.
Zitat • Psychological stress induces aging-like dysfunction in HSCs • mPFC/PAG suppression impairs HSCs through sympathetic gut signaling • Stress reduces L. reuteri and spermidine to promote ferroptotic stress in HSCs • Spermidine restores autophagy and HSC function under psychological stress
Zitat • Chronic stress leads to the translocation of gut Enterococcus gallinarum to tumors • Eg phage DNA induces glucocorticoid production by cancer-associated fibroblasts via TLR9 • Intratumor glucocorticoids suppress anti-tumor GC B cells via the glucocorticoid receptor • Targeting intratumor TLR9 or Eg rescues GC B cells and restores anti-tumor immunity