RE: Grüner Kaffee - 2

Identification of senescence related hub genes and potential therapeutic compounds for dilated cardiomyopathy via comprehensive transcriptome analysis
https://www.sciencedirect.com/science/ar..._wK9zexEuobjcmg

Zitat

---

•
Chlorogenic acid (CGA) ameliorates rheumatoid arthritis in CIA mice in a gut microbiota-dependent manner.
•
CGA reshapes gut microbiota composition, notably enriching Lactobacillus and promoting indolelactic acid (ILA) production.
•
CGA restores the Treg/Th17 balance in CIA mice, contributing to its immunomodulatory effects.
•
The anti-inflammatory effect of ILA is mediated through inhibition of NF-κB p65 phosphorylation.
•
This study reveals a novel mechanism by which CGA targets the gut microbiota–metabolite–immune axis to treat RA.

---

Chlorogenic acid attenuates rheumatoid arthritis by modulating immunity via the gut microbiota-derived metabolite indolelactic acid
https://www.sciencedirect.com/science/ar...567576926005266