RE: Sarkopenie - 3

Arginase-II gene deficiency reduces skeletal muscle aging in mice
https://www.aging-us.com/article/206173/text

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
https://onlinelibrary.wiley.com/doi/10.1002/mco2.70030

Hallo Speedy,

bei Kachexie hat Dr. Kremer mit guten Ergebnissen u.a. hochdosiertes ACC/NAC sowie Glutamin verordnet (je nach Laborwert): z.B. täglich 2400 mg NAC und täglich > 2400 mg Glutamin.

Viele Grüße

Roger

Reactive oxygen species in the pathogenesis of sarcopenia
https://www.sciencedirect.com/science/ar...891584924010803

Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing
https://link.springer.com/article/10.118...8rUP55_4m6YkOww

An mTOR paradox in sarcopenia via BCAA catabolism
https://www.nature.com/articles/s43587-025-00815-3

5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept
https://link.springer.com/article/10.100...aMfPuEW2ZRelFPg

Es reduziert den Appetit, indem es den Serotoninrezeptor (5- HT2C- Rezeptor) im Hypothalamus aktiviert, einer Gehirnregion, die bekanntermaßen den Appetit kontrolliert. Es wurde 2012 zugelassen und 2020 in den USA vom Markt genommen, da bei Anwendern von Belviq ein erhöhtes Krebsrisiko festgestellt wurde.
Es geht um Lorcaserin.

Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans
https://www.sciencedirect.com/science/ar...2459?via%3Dihub

Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia
https://www.nature.com/articles/s41467-025-61403-y

Hallo,

Muskelschwund ab 20? Dr. Kurt Mosetter: https://www.youtube.com/watch?v=jVOakN9Xip4 .

VG

Roger

Neuer Post von Louis Dischler (bekannt auch als Turnbuckle bei LongeCity in der Vergangenheit).

REVERSING SARCOPENIA
https://www.linkedin.com/pulse/reversing...-dischler-kuvze

Hallo,

Sarkopenie erfolgreich abfedern (Dr. Kurt Mosetter, Konstanz): siehe auch Link.

VG

Roger

Zitat von Speedy im Beitrag #62

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Neuer Post von Louis Dischler (bekannt auch als Turnbuckle bei LongeCity in der Vergangenheit).

REVERSING SARCOPENIA
https://www.linkedin.com/pulse/reversing...-dischler-kuvze

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Zitat

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Conclusions: BDP and leucine show superior efficacy in ameliorating sarcopenia, through multimodal regulation of multiple signaling pathways, offering a promising plant-based nutritional strategy against age-related muscle decline.

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Broccoli-Derived Peptides and Leucine in Combination Ameliorate D-Galactose-Induced Sarcopenia in Mice
https://www.mdpi.com/2072-6643/18/12/1997

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise
https://onlinelibrary.wiley.com/doi/10.1002/jcp.70212

Zitat von Speedy im Beitrag #64

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Zitat von Speedy im Beitrag #62

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Neuer Post von Louis Dischler (bekannt auch als Turnbuckle bei LongeCity in der Vergangenheit).

REVERSING SARCOPENIA
https://www.linkedin.com/pulse/reversing...-dischler-kuvze

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REVERSING SARCOPENIA AND INCREASING MUSCLE MASS WITHOUT EXERCISE
https://www.linkedin.com/pulse/reversing...ed-content-card

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Zitat

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Imeglimin attenuates skeletal muscle atrophy in obesity and ageing, accompanied by coordinated suppression of stress- and inflammation-associated transcriptional programmes. These findings indicate that pharmacological regulation of mitochondrial stress responses influences skeletal muscle vulnerability under chronic metabolic stress and identify skeletal muscle as a previously underappreciated target of imeglimin action.

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Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing
https://onlinelibrary.wiley.com/doi/10.1002/jcsm.70354