RE: Astragalus - 3

Zitat von Prometheus im Beitrag #51

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Astragalus war bei mir nicht effektiv.

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Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment

Zitat

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We found that astragalus polysaccharides can promote the activities of macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes and induce the expression of a variety of cytokines and chemokines. Furthermore, we summarized the clinical applications of astragalus polysaccharides in patients with digestive tract tumors. We summarized the effective mechanism of astragalus polysaccharides on digestive tract tumors, including apoptosis induction, proliferation inhibition, immunoactivity regulation, enhancement of the anticancer effect and chemosensitivity.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517906/

Kommentar: Vielleicht auch als Immunmodulator denkbar,

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Zitat

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Astragalus polysaccharide is a natural bioactive component and possesses a variety of biological activities involved in anti-oxidation, anti-aging, anti-fibrosis, anti-tumor, antiviral and antibacterial, blood sugar reduction, blood lipid reduction, anti-fibrosis, and radiation protection effects. Furthermore, emerging evidence demonstrated that APS plays a potential role in intestinal epithelial barrier integrity maintenance, intestinal microbiota regulation, immune response, and redox homeostasis, which are critical for intestinal health, immune response, and animal’s growth performance. It can provide reference for further study on the effect of APS on intestinal barrier. In addition, it can be seen from the above numerous reports that Astragalus polysaccharide is widely used in the intestine, and there will be some breakthroughs in the future.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096541/

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

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The dry root of the soybean plant Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao or A. membranaceus (Fisch) Bge, Astragali Radix (AR) has a long medicinal history. Astragalus polysaccharide (APS), the natural macromolecule that exhibits immune regulatory, anti-inflammatory, anti-tumor, and other pharmacological activities, is an important active ingredient extracted from AR. Recently, APS has been increasingly used in cancer therapy owing to its anti-tumor ability as it prevents the progression of prostate, liver, cervical, ovarian, and non-small-cell lung cancer by suppressing tumor cell growth and invasion and enhancing apoptosis. In addition, APS enhances the sensitivity of tumors to antineoplastic agents and improves the body’s immunity. This macromolecule has prospects for broad application in tumor therapy through various pathways.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10955345/

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

Zitat

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Astragalus polysaccharide (APS) derived from A. membranaceus plays a crucial role in traditional Chinese medicine. These polysaccharides have shown antitumor effects and are considered safe. Thus, they have become increasingly important in cancer immunotherapy. APS can limit the spread of cancer by influencing immune cells, promoting cell death, triggering cancer cell autophagy, and impacting the tumor microenvironment. When used in combination with other therapies, APS can enhance treatment outcomes and reduce toxicity and side effects.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11124422/

Pharmacological effects of Astragalus polysaccharides in treating neurodegenerative diseases
https://www.frontiersin.org/journals/pha...24.1449101/full

Mit Astragalus-Extrakt und Gotu Kola-Extrakt habe ich auch gute Erfahrungen gemacht. Wobei ich von dem Astragalus-Extrakt manchmal Kopfschmerzen bekomme, vor allem wenn ich noch viele andere NEMs nehme. Die Wirkung selbst ist schwer zu beschreiben, man hat einfach das Gefühl, dass es leicht positiv wirkt. Gotu Kola soll ja leider nicht so gut für T sein.

Formononetin Defeats Multidrug-Resistant Cancers by Induction of Oxidative Stress and Suppression of P-Glycoprotein
https://www.mdpi.com/1422-0067/25/15/8471

Harter Take zu TA-65:

Zitat

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This study elucidated novel functions of Telomerase in ovarian ageing. The findings of this study indicate that downregulation of TERT and Klb occurs in mouse ovarian ageing. The binding of CAG to the three-dimensional structure of hTERT revealed that CAG is an effective telomerase activator. CAG-activated Telomerase not only upregulate Klb protein level but also improved mitochondrial functioning (non-nuclear function of Telomerase) to reduce the ovarian damage caused by D-gal or DOX. Furthermore, ovarian follicles are irreparably harmed by Doxorubicin therapy, utilized in the treatment of ovarian cancer. However, CAG prevented the harmful effects of Doxorubicin on the ovarian follicular pool.

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https://www.sciencedirect.com/science/ar...047637422001385

Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice

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By screening a series of compounds, we found that CAG selectively kills SCs by inducing SCs apoptosis and that this process is associated with the inhibition of Bcl-2 antiapoptotic family proteins and the PI3K/AKT/mTOR pathway. In addition, CAG treatment also suppressed the development of the senescence-associated secretory phenotype (SASP) in SCs, thereby inhibiting cell migration mediated by the SASP. Furthermore, the administration of CAG for 2 weeks to mice with irradiation-induced aging alleviated the burden of SCs and improved the animals’ age-related physical dysfunction. Overall, our studies demonstrate that CAG is a novel senolytic agent with in vivo activity that has the potential to be used in the treatment of age-related diseases.

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10095196/

Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia

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Our findings suggest that CAG is neuroprotective against ischemic brain injury in mice and that its beneficial effect may involve SIRT1 upregulation and the inhibition of apoptosis and neuroinflammation in the ischemic brain.

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https://pmc.ncbi.nlm.nih.gov/articles/PMC7471431/

Cycloastragenol exerts protective effects against UVB irradiation in human dermal fibroblasts and HaCaT keratinocytes
https://pubmed.ncbi.nlm.nih.gov/37474410/

Hier gäbe es z.B. einen Anbieter für Cycloastragenol mit Labortest (10mg/Kapsel): https://de.prohealth.com/products/prohea...-capsules-ph685
Rechnerisch wäre das deutlich günstiger als die derzeit 98€ teuren TA-65, welche 10mg "Astragalus-Wurzel-Extrakt" enthalten sollen. Ob es letztlich auch nur Cycloastragenol ist oder doch eine "geheime" Formulierung, kann ich nicht mit absoluter Sicherheit sagen. Laut Wikipedia scheint es indentisch zu sein: https://en.wikipedia.org/wiki/Cycloastragenol
Hier nochmal günstigeres Cycloastragenol, aber gerade nicht lieferbar (und anscheinend auch ohne Labortest): https://kenayeurope.de/gesunde-nahrungse...ungsmittel.html

#59
Cycloastragenol muss man wohl sehr hoch dosieren um einen möglichen Effekt auf die Telomerlänge zu erreichen. Mit nur 10 mg wird das definitiv nicht nennenswert funktionieren. Gibt bei Reddit zum Beispiel Erfahrungsberichte dazu mit genauer Bestimmung. Mit Sprints wird man vermutlich mehr erreichen und ist kostenlos zudem.

Zitat von Speedy im Beitrag #60

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#59
Cycloastragenol muss man wohl sehr hoch dosieren um einen möglichen Effekt auf die Telomerlänge zu erreichen. Mit nur 10 mg wird das definitiv nicht nennenswert funktionieren. Gibt bei Reddit zum Beispiel Erfahrungsberichte dazu mit genauer Bestimmung. Mit Sprints wird man vermutlich mehr erreichen und ist kostenlos zudem.

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#61
Die Reinsubstanz wäre sinnvoll. Cycloastragenol löst sich recht gut in DMSO und transdermal sollte funktionieren (nicht DMSO pur auftragen natürlich).

Zitat von Speedy im Beitrag #62

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Die Reinsubstanz wäre sinnvoll. Cycloastragenol löst sich recht gut in DMSO und transdermal sollte funktionieren (nicht DMSO pur auftragen natürlich).

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Effect of Astragalus injection treatment for viral myocarditis: a systematic review and meta-analysis
https://link.springer.com/article/10.1186/s40001-024-02193-9

The Effects of a Novel Astragalus-Based Extract (Keyfobell Powder (KFB)) on Longitudinal Bone Growth via IGF-1 Upregulation: A Potential Growth Hormone Alternative
https://www.mdpi.com/2072-6643/17/3/416#