RE: Astragalus - 3

Zitat von Prometheus im Beitrag #51

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Astragalus war bei mir nicht effektiv.

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Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment

Zitat

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We found that astragalus polysaccharides can promote the activities of macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes and induce the expression of a variety of cytokines and chemokines. Furthermore, we summarized the clinical applications of astragalus polysaccharides in patients with digestive tract tumors. We summarized the effective mechanism of astragalus polysaccharides on digestive tract tumors, including apoptosis induction, proliferation inhibition, immunoactivity regulation, enhancement of the anticancer effect and chemosensitivity.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517906/

Kommentar: Vielleicht auch als Immunmodulator denkbar,

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Zitat

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Astragalus polysaccharide is a natural bioactive component and possesses a variety of biological activities involved in anti-oxidation, anti-aging, anti-fibrosis, anti-tumor, antiviral and antibacterial, blood sugar reduction, blood lipid reduction, anti-fibrosis, and radiation protection effects. Furthermore, emerging evidence demonstrated that APS plays a potential role in intestinal epithelial barrier integrity maintenance, intestinal microbiota regulation, immune response, and redox homeostasis, which are critical for intestinal health, immune response, and animal’s growth performance. It can provide reference for further study on the effect of APS on intestinal barrier. In addition, it can be seen from the above numerous reports that Astragalus polysaccharide is widely used in the intestine, and there will be some breakthroughs in the future.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096541/

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Zitat

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The dry root of the soybean plant Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao or A. membranaceus (Fisch) Bge, Astragali Radix (AR) has a long medicinal history. Astragalus polysaccharide (APS), the natural macromolecule that exhibits immune regulatory, anti-inflammatory, anti-tumor, and other pharmacological activities, is an important active ingredient extracted from AR. Recently, APS has been increasingly used in cancer therapy owing to its anti-tumor ability as it prevents the progression of prostate, liver, cervical, ovarian, and non-small-cell lung cancer by suppressing tumor cell growth and invasion and enhancing apoptosis. In addition, APS enhances the sensitivity of tumors to antineoplastic agents and improves the body’s immunity. This macromolecule has prospects for broad application in tumor therapy through various pathways.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10955345/

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

Zitat

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Astragalus polysaccharide (APS) derived from A. membranaceus plays a crucial role in traditional Chinese medicine. These polysaccharides have shown antitumor effects and are considered safe. Thus, they have become increasingly important in cancer immunotherapy. APS can limit the spread of cancer by influencing immune cells, promoting cell death, triggering cancer cell autophagy, and impacting the tumor microenvironment. When used in combination with other therapies, APS can enhance treatment outcomes and reduce toxicity and side effects.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11124422/

Pharmacological effects of Astragalus polysaccharides in treating neurodegenerative diseases
https://www.frontiersin.org/journals/pha...24.1449101/full

Mit Astragalus-Extrakt und Gotu Kola-Extrakt habe ich auch gute Erfahrungen gemacht. Wobei ich von dem Astragalus-Extrakt manchmal Kopfschmerzen bekomme, vor allem wenn ich noch viele andere NEMs nehme. Die Wirkung selbst ist schwer zu beschreiben, man hat einfach das Gefühl, dass es leicht positiv wirkt. Gotu Kola soll ja leider nicht so gut für T sein.

Formononetin Defeats Multidrug-Resistant Cancers by Induction of Oxidative Stress and Suppression of P-Glycoprotein
https://www.mdpi.com/1422-0067/25/15/8471