RE: Long Covid - 23

Plasma cell targeting with the anti-CD38 antibody daratumumab in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) -a clinical pilot study
https://www.frontiersin.org/journals/med...607353/abstract

SARS-CoV-2 causes gastric damage: structural and ultrastructural evaluation
https://link.springer.com/article/10.1007/s10735-025-10477-5

Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy

https://www.researchsquare.com/article/rs-6596158/v1

Kommentar: Preprint, geringe Probandenzahl, keine Kontrollgruppe, hohe Dropout-Rate. Dafür zeigte Rapamycin bei 72.5% der verbliebenen Probanden eine hohe Effektstärke und war gut verträglich. Da sich Post Covid mit Fatiguesymptomatik und ME/CFS pathophysiologisch ähneln, könnte Rapamycin eine wirksame Off-Label-Therapie darstellen.

Hallo,

die GABA-Shunt-Hypothese ermöglicht evtl. neue Therapieansätze: https://ganzemedizin.at/me-cfs-gaba-shunt/ .

VG

Roger

Immunological and Clinical Markers of Post-acute Sequelae of COVID-19: Insights from Mild and Severe Cases 6 Months Post-infection
https://onlinelibrary.wiley.com/doi/10.1002/eji.202551948

Viral Mitochondriopathy in COVID-19
https://www.sciencedirect.com/science/ar...213231725002794

What a disease in cats may teach us about long COVID
https://medicalxpress.com/news/2025-07-d...o_pGOQpCYLHVIYg

Neurological and Immunological Insights Into Post-COVID-19 Syndrome: A Single-Center Retrospective Study
https://www.cureus.com/articles/348229-n...ective-study#!/

Oxidative stress is a shared characteristic of ME/CFS and Long COVID
https://www.pnas.org/doi/abs/10.1073/pna...cr_pub++0pubmed

Safety, tolerability and clinical effects of rovunaptabin, also known as BC007 on fatigue and quality of life in patients with Post-COVID syndrome (reCOVer): a prospective, exploratory, placebo-controlled, double-blind, randomised phase IIa clinical trial (RCT)
https://www.thelancet.com/journals/eclin...0290-1/fulltext

A Systematic Review of Genetic Variants in Glutathione S-Transferase Genes and Their Dual Role in SARS-CoV-2 Pathogenesis: From Acute Respiratory Complications to Long COVID
https://www.mdpi.com/2076-3921/14/8/912

Your Gut May Be the Key to Chronic Fatigue, Long COVID
https://neurosciencenews.com/chronic-fat...crobiome-29530/

The Role of SARS-CoV-2 Nucleocapsid Protein in Host Inflammation
https://www.mdpi.com/1999-4915/17/8/1046