RE: Long Covid - 22

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
https://www.medrxiv.org/content/10.1101/...5.02.25326885v1

What exactly is brain fog? Here’s what scientists are finding out.
https://www.nationalgeographic.com/healt...rain-fog-causes

Palmitoylated COX-2Cys555 reprogramed mitochondrial metabolism in pyroptotic inflammatory injury in patients with post-acute COVID-19 syndrome
https://www.sciencedirect.com/science/ar...090123225002991

Age-associated changes in the heart: implications for COVID-19 therapies
https://www.aging-us.com/article/206251/...ez43vRrocT28Dyg

Association between COVID-19 and the development of chronic kidney disease in patients without initial acute kidney injury

https://www.nature.com/articles/s41598-025-96032-4

Zitat

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COVID-19 patients showed higher 12-month risks of advanced CKD (hazard ratio [HR]:2.02, 95% confidence interval [CI]:1.69–2.42, p < 0.0001), AKI (HR 3.04, 95%CI:2.61–3.55, p < 0.0001), and estimated glomerular filtration rate < 60 mL/min/1.73 m2 (HR:3.01, 95%CI:2.74–3.30, p < 0.0001) compared to influenza patients.

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Kommentar: Das reiht sich nahtlos in die Fülle der Studien ein, die zeigen, dass eine SARS-CoV-2-Infektion Organe langfristig schädigen kann, besonders die mit niedriger Regenerationskapazität (Nieren, Gehirn).

SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations
https://www.sciencedirect.com/science/ar...090123225003066

Spermidin Infusionen wären meiner Ansicht nach hier ein möglicher Therapie Ansatz. Infusionen da die orale Route hier vermutlich nur sehr geringe Effekte zeigen dürfte.

Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients
https://onlinelibrary.wiley.com/doi/10.1111/all.16593

Adenosine deaminase mediates endothelial inflammation via an ADA1-CD26 interaction in post-COVID
https://www.frontiersin.org/journals/pha...25.1578973/full

Low-Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients
https://www.frontiersin.org/journals/mol...25.1582967/full

Elevated adipokines and myokines are associated with fatigue in long COVID patients
https://www.frontiersin.org/journals/med...25.1547886/full

Myostatin und Irisin. Dann dürfte theoretisch von Sulforaphan, Kreatin oder dem Peptid MOTS- c profitiert werden. Pinealon soll regulierend auf Irisin wirken.

COVID virus 'reprograms' infection fighters into immune system suppressors, study shows
https://medicalxpress.com/news/2025-05-c...qdnMUVsxqO2-0oQ

Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease
https://www.sciencedirect.com/science/ar...889159125001977

Zitat von Speedy im Beitrag #534

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COVID virus 'reprograms' infection fighters into immune system suppressors, study showshttps://medicalxpress.com/news/2025...qdnMUVsxqO2-0oQ

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Targeting the epipharynx to disrupt the residual triggers of COVID-19 in patients with long COVID
https://medicalxpress.com/news/2025-05-e...eZOwpCC0a4cuqOw

Exercise-induced Changes in Microclotting and Cytokine Levels Point to Vascular Injury and Inflammation in People with Long COVID
https://www.researchsquare.com/article/rs-6717727/v1

A Proposed Mechanism for ME/CFS Invoking Macrophage FcγRI and Interferon Gamma
https://www.qeios.com/read/8GI3CT

Exploring the role of mitochondrial dysfunction and aging in COVID-19-Related neurological complications
https://link.springer.com/article/10.1007/s11033-025-10586-0

Post-COVID pulmonary sequelae: Mechanisms and potential targets to reduce persistent fibrosis
https://www.sciencedirect.com/science/ar...163725825001032

NAC wird häufig in einem Long Covid Regime eingesetzt. Viele beachten aber nicht, dass Bromelain unbedingt dazu gehört.

The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2
https://pmc.ncbi.nlm.nih.gov/articles/PM...QLRTGivw5e3kzDQ