RE: Wachstumshormon/IGF-1 - 6

IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons
https://www.aging-us.com/article/204360/text

Man müsste sich Gedanken machen wie sich die POLD1 Expression ankurbeln lässt mit eventuell natürlichen Substanzen.

IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression
https://www.besjournal.com/en/article/do...967/bes2022.127

@Speedy
das besteht genauso die Crux , wie bei der Verlängerung der Telomere, nämlich die krebsfördernde Seite.
Scheinbar verstärkt bei älteren Männern:

https://www.focus.de/gesundheit/gesundle...id_1968363.html

Zitat von Speedy im Beitrag #127

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Man müsste sich Gedanken machen wie sich die POLD1 Expression ankurbeln lässt mit eventuell natürlichen Substanzen.

IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression
https://www.besjournal.com/en/article/do...967/bes2022.127

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Insulin-Like Growth Factor I Modulates Sleep Through Hypothalamic Orexin Neurons
https://www.biorxiv.org/content/10.1101/...0.000000v1.full

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
https://www.biorxiv.org/content/10.1101/2025.06.03.656903v1

Growth hormone excess drives liver aging via increased glycation stress
https://www.aging-us.com/article/206327/text

Silencing Growth Hormone Has Strong Effects in Mouse Brains
https://lifespan.io/news/silencing-growt...dhAbPp8cdVNCaSQ

Zitat

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In this light, strategies that target the expansion of mtDNA mutations, rather than their origin, may offer a powerful new axis for preserving tissue function and extending health span, even when the underlying genomic damage cannot be undone.

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The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
https://www.science.org/doi/10.1126/scia...HgTdpJicp0X8glg

Zitat

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Both compounds protected both sexes from short-term memory decline; reduced systolic blood pressure in males and pulse rate in both sexes; rescued declining glucose tolerance in males; and abolished grey hair development, reduced frailty, and protected against decline in grip strength in female mice.

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Small-molecule IGF1R inhibitors extend healthspan in a mouse model
https://www.biorxiv.org/content/10.64898...CypLooq10GbV8aQ

Interessant dass auch das Ergrauen der Haare zumindest bei weiblichen Mäusen gestoppt wurde. NDGA wäre eine natürliche Option mit der Prometheus aber nicht wirklich Erfolg hatte. Vielleicht funktioniert es auch wirklich nur bei Frauen.

Young Blood Needs a Receptionist: IGF-1 Rejuvenates Brain’s Vessels and Blood Barrier
https://www.rapamycin.news/t/young-blood...d-barrier/26222

Zitat

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Here we show that ubiquitous degradation of DAF-2 in male C. elegans increases median lifespan by more than 440%, one of the longest lifespan extensions by a single intervention to date.

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Disruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life
https://www.aging-us.com/article/206411/...ElOzZia5mZkig_Q

@Prometheus
Schon beeindruckend diese 440%.