Lavender essential oil alleviates depressive-like behavior in alcohol-withdrawn rats: Insights from gut metabolites and hippocampal transcriptome analysis
Zitat• Inhalation of lavender essential oil ameliorates behavioral abnormalities in alcohol withdrawal-induced depressive rats, as evidenced by improvements in sucrose preference, open field, and forced swim tests. • Lavender essential oil inhalation alters the gut microbiota composition of alcohol withdrawal rats, increasing the relative abundance of Muribaculaceae. • Lavender essential oil inhalation improves gut metabolites in alcohol withdrawal rats. • Transcriptomic analysis reveals that lavender essential oil regulates inflammatory factors and gene expression in the hippocampus, downregulating the inflammation-related Trpv4 gene.