RE: News aus der Forschung - 6

Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks
https://www.mdpi.com/1422-0067/25/12/679...QNZGr4h9b_kiQQ#

The chemical language of protein glycation
https://www.nature.com/articles/s41589-0...llwafBdScGLW6Vw

Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?
https://www.aging-us.com/article/205975/text

Regulation of blood-brain barrier integrity by Dmp1-expressing astrocytes through mitochondrial transfer
https://www.science.org/doi/10.1126/sciadv.adk2913

Zitat von Prometheus im Beitrag #84

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Zitat von Speedy im Beitrag #83

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Turning back the ageing clock with MonaJuventa Nu
https://nutraceuticalbusinessreview.com/...5UnGpXqa2QmkeHj

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Zitronenmelisse und Indianernessel. Da mag was dran sein, allerdings habe ich die Studie dazu nirgendwo finden können?

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Hallo Prometheus,
so wie es aussieht wurden bis jetzt noch keine Forschungsergebnisse veröffentlicht.

Siehe hier:
https://www.nutraingredients.com/Article...pigenetic-aging


Die 2 entsprenchenden Abschnitte sind hier mal reinkopiert:

Unpublished research conducted by Mibelle Biochemistry indicates that MonaJuventa Nu's potential to act
on eight of those markers, including mitochondrial ATP production, vascular function (by increasing nitric oxide release)
and protection from oxidative stress.

sowie:

Further unpublished data from a human fibroblast study found a 40% reduction in epigenetic age.
Results were assessed using the Horvath Pan-Tissue Clock, which uses DNA methylation patterns to
estimate biological age across various tissues.

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Ich liebe Zitronenmelisse!!!
Ich Pflanze mir eine Wiese davon und wälze mich darin. Versprochen nächstes Jahr.

Embryo's signaling mechanism may promote healthy aging, combat neurodegenerative diseases

Zitat

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Northwestern investigators have identified a novel transcription factor that regulates a signaling mechanism utilized by a fertilized embryo to protect its mother from cellular and environmental stress, according to a study to published in the journal Genes & Development.

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https://medicalxpress.com/news/2024-07-e...ing-combat.html

Die Studie:
Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues
https://genesdev.cshlp.org/content/early.../gad.351829.124

Zitat von version2 im Beitrag #25

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Re-energizing mitochondria to treat Alzheimer’s disease

Zitat

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The researchers hypothesized that if they could supply some of the missing succinate molecules, they might be able to restore energy production—essentially jumpstarting the stalled mitochondrial Krebs cycle. Since succinate does not easily travel in or out of cells, they used an analog that could better pass through nerve cell membranes. The strategy worked, repairing up to three quarters of the synapses that had been lost, while preventing further decline.

“Succinate is not a compound that people can now take as a treatment, but it’s proof-of-principle that you can re-energize the Krebs cycle,” says Lipton. “The beauty of the study is that we were able to show this in living nerve cells derived from Alzheimer’s patients, but we still have to come up with a much better compound in order to develop an effective drug for humans to take.”

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https://www.scripps.edu/news-and-events/...alzheimers.html

Metabolic Bypass Rescues Aberrant S-nitrosylation-InducedTCA Cycle Inhibition and Synapse Loss in Alzheimer’s Disease Human Neurons
https://onlinelibrary.wiley.com/doi/epdf.../advs.202306469

Kommentar: Anscheinend wurde dimethyl succinate (deutsch: Bernsteinsäuredimethylester) genutzt. Laut Zitat oben jedoch nicht supplementierbar(?)

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Theoretisch schon für einen kurzen Zeitraum. Rein experimenteller Ansatz natürlich in dem Fall der aber spannend ist auch bzgl. Long Covid.

An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
https://genomemedicine.biomedcentral.com...T5YRwRI5dAYwBoA

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation
https://www.biorxiv.org/content/10.1101/2024.07.04.601982v1

https://www.nature.com/articles/s41551-024-01227-1
Bessere effizientere Gentherapie eePASSIGE .
Habe hier glaube noch nichts dazu gehört.

https://ga.de/news/wissen-und-bildung/re...r_aid-116083619
Blutblättchen sprechen mit Monozyten.
Hilft vielleicht Adlige-Bluter, deren Vorfahren auf wenig Bluttplättchen, wenig Entzündugs- Therapie setzten (VT). Oder ein weiterer Wirkungsweg des Aspirins.

Mitochondria May Have Been Wrongly Accused in DNA Damage
https://www.the-scientist.com/mitochondr...na-damage-71999

Longevity drug? Study finds taking Ozempic/Wegovy may also benefit brain health
https://longevity.technology/news/longev...t-brain-health/

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
https://www.nature.com/articles/s41586-0...StYGmUs4JmOtctA

Naturally occurring peptide could serve as a novel protective agent for 'inflammaging'
https://medicalxpress.com/news/2024-07-n...TQQ_o4BMXA9xMfQ

https://www.nature.com/articles/s41586-024-07701-9
Interleukin-11-Hemmung wirkt positiv auf Alterungsprozesse
https://pubmed.ncbi.nlm.nih.gov/34533646/
Bei Wasserstoff wird nur Interleukin 6 erwähnt aber das gehört zumindest zur Familie. Wäre schlimm wieder so viel Zeug zu schlucken nur weil IL-11 nicht erwähnt wird. Ein kleinen Knacks im Placebo macht es aber schon

IMG_20230922_135551.jpg - Bild entfernt (keine Rechte)
Wasserstoff Therapie für Katzen, schwierig.
Wie bekommt man eine Nasenbrille in die Viecher? Aber vielleicht diffundiert etwas durch mich? Katzen sind blöde Test-Objekte

Zitat von Speedy im Beitrag #138

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Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
https://www.nature.com/articles/s41586-0...StYGmUs4JmOtctA

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Zitat von Illuminatus im Beitrag #140

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https://www.nature.com/articles/s41586-024-07701-9
Interleukin-11-Hemmung wirkt positiv auf Alterungsprozesse
https://pubmed.ncbi.nlm.nih.gov/34533646/

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#142
Alternative Möglichkeiten IL-11 zu hemmen wären halt interessant. Die man bereits jetzt aktiv umsetzen kann.

Loss of H3K9 trimethylation leads to premature aging
https://www.biorxiv.org/content/10.1101/2024.07.24.604929v1

Cheap Daily Supplement Seems to Boost Brain Function in Older People
https://www.sciencealert.com/cheap-daily...in-older-people

Check. Inulin kommt seit jeher in meinen selbstgemachten Joghurt und in den Proteinshake.

TERT activation targets DNA methylation and multiple aging hallmarks
https://www.cell.com/cell/abstract/S0092...w-rRPF-wgSgXKw#

Zitat von Timar im Beitrag #145

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Inulin kommt seit jeher in meinen selbstgemachten Joghurt und in den Proteinshake.

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https://www.webmd.com/lupus/news/2024071...cure-identified

Lupus, bald heilbar?

A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells

Zitat

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In this study, we created a metabolome atlas of different blood cells across ages in mice. We reveal here that purine, pyrimidine and retinol metabolism are enriched in young hematopoietic stem and progenitor cells (HSPCs), whereas glutamate and sphingolipid metabolism are concentrated in aged HSPCs. Through metabolic screening, we identified uridine as a potential regulator to rejuvenate aged HSPCs. Mechanistically, uridine treatment upregulates the FoxO signaling pathway and enhances self-renewal while suppressing inflammation in aged HSCs.

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https://www.nature.com/articles/s43587-024-00669-1

Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing

Zitat

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Several supplements, including MitoQ, urolithin A, omega-3 polyunsaturated fatty acids (n3-PUFAs), and a combination of glycine and N-acetylcysteine (GlyNAC) can improve physical function in older individuals through a variety of inter-dependent mechanisms including increases in mitochondrial biogenesis and energetics, decreases in mitochondrial reactive oxygen species emission and oxidative damage, and improvements in mitochondrial quality control.

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https://link.springer.com/article/10.1007/s40279-024-02072-7

Hat hier jemand Erfahrungen mit Uridin?

Zitat von version2 im Beitrag #149

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Hat hier jemand Erfahrungen mit Uridin?

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