RE: Ginseng - 4

Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora
https://www.sciencedirect.com/science/ar...4445?via%3Dihub

Long-term evaluation of safety and biological effects of Korean Red Ginseng (Panax Ginseng): a long-term in vivo study
https://bmccomplementmedtherapies.biomed...906-022-03736-5

Panax ginseng Meyer cv. Silvatica phenolic acids protect DNA from oxidative damage by activating Nrf2 to protect HFF-1 cells from UVA-induced photoaging
https://pubmed.ncbi.nlm.nih.gov/36328205/

Red ginseng extract improves skeletal muscle energy metabolism and mitochondrial function in chronic fatigue mice
https://www.frontiersin.org/articles/10....22.1077249/full

Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction: https://pubmed.ncbi.nlm.nih.gov/19234482/


Infos mit vielen Studien zur Wirkungsweise: https://herbano.com/de/ratgeber/ginseng



Es werden ja viele Produkte unter Ginseng angeboten. Vieles ist Schrott.

Maßgebend ist die Bezeichnung Panax Ginseng CA Meyer.

Wegen NW abgesetzt! Früher hatte ich Ginseng besser vertragen.

Zitat

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Welche unerwünschten Wirkungen können auftreten?

Überempfindlichkeit, wie:
Nesselausschlag (Urtikaria) durch Medikamente
Allergischer Juckreiz
Magen-Darm-Beschwerden, wie:
Übelkeit
Erbrechen
Durchfall
Verstopfung
Schlaflosigkeit

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Research Progress on the Anti-Aging Potential of the Active Components of Ginseng

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Ginsenosides are the most widely studied active ingredients, and ginsenoside monomers, such as Rg1, Rg3, Rb1, and Rc, have shown strong anti-aging effects and demonstrated good therapeutic effects against neurodegenerative disease, diabetes, skin aging, muscle atrophy, and other age-related diseases [167,168,169,170,171]. The active ingredients of ginseng mainly contribute to aging delay through the following mechanisms: (1) the increase in the expression of antioxidant enzymes to achieve a balance between intracellular oxidation and antioxidation, the mitigation of excessive production of ROS, and the reduction in endogenous DNA damage, which prevent cell cycle arrest and delay aging; and (2) the regulation of the activities of DNA glycosylase and sirtuins in the process of DNA damage repair to ensure that the DNA repair pathway can accurately repair DNA damage caused by various factors associated with aging.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421173/

Kommentar: Reduzierung von DNA-Schäden auf jeden Fall spannend. Spräche was gegen eine langfristige Einnahme, wenn man keine NW bemerkt?

How ginseng regulates autophagy: Insights from multistep process

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Ginseng regulates the development of numerous diseases through inducing or inhibiting the multistep processes of autophagy. Ginseng extracts and active components that are isolated from ginseng, especially ginsenosides, mediate numerous autophagy-related pathways, such as mTOR, AMPK signaling, PI3K/AKT pathway, and p62-Keap1-Nrf2 axis. Currently, the therapeutic role of ginseng-mediated autophagy in cancers, brain diseases, and heart diseases have been widely acknowledged, corroborating ginseng as the potential drug candidates in these fields. We have also discussed the complicated relationship between ginseng-regulated autophagy and apoptosis in cancer. Autophagy and apoptosis work either synergistically or antagonistically in determining cancer cell fate, revealing the potential and importance of combining both ginseng’s mode of action, i.e., autophagy and apoptosis. Although the understanding of the therapeutic effects of ginseng has expanded in recent years, a comprehensive review of ginseng as an autophagy-targeting therapeutic agent is not yet available.

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https://www.sciencedirect.com/science/ar...753332222015281

Auch wissenswert:

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In Europa bekommen wir meist Weißen Ginseng, dessen Extrakt in der Regel um die vier Prozent Ginsenoside enthält. Japanischer Roter Ginseng bietet um die acht Prozent dieser bioaktiven Stoffe.

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https://www.heilpraxisnet.de/heilpflanzen/ginseng/

Ginsenoside könnten eine erste Orientierungshilfe bei der Wahl des Extraktes bieten.

Red Ginseng Attenuates the Hepatic Cellular Senescence in Aged Mice

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The aim of this study was to explore the potential impact of red ginseng (RG) on age-associated cellular senescence through in vitro, ex vivo, and 19-month-old aged mouse models. In addition to enhancing insulin homeostasis, RG supplementation modified the canonical cellular senescence pathway and inhibited apoptotic markers. Moreover, RG significantly reduced the senescence-associated inflammatory pathway in the liver. Finally, the RG treatment mitigated cellular senescence in primary hepatocytes and mouse embryonic fibroblasts. In conclusion, these findings suggest that RG has a positive influence on the aging process by regulating hepatic cellular senescence and age-related phenotypes.

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https://www.mdpi.com/2079-7737/13/1/36

Zitat von Prometheus im Beitrag #86

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Ginseng wirkt über SKN-1/Nrf2 und DAF-16/FOXO für den Rundwurm lebensverlängernd:

Low methyl-esterified ginseng homogalacturonan pectins promote longevity of Caenorhabditis elegans via impairing insulin/IGF-1 signalling
https://www.sciencedirect.com/science/ar...144861724008269

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Antiviral potential of ginseng: Targeting human pathogenic viruses with compounds derived from ginseng
https://www.sciencedirect.com/science/ar...226845324001623

Compound K promotes thermogenic signature and mitochondrial biogenesis via the UCP1-SIRT3-PGC1α signaling pathway
https://www.sciencedirect.com/science/ar...753332225000320

Korean Red ginseng-induced astrocytic HIF-1α: A key regulator of neuroglobin derived from neural stem cell differentiation in physiologic retina and brain
https://www.sciencedirect.com/science/ar...226845324001775

Ginseng in Delaying Brain Aging: Progress and perspectives
https://www.sciencedirect.com/science/ar...944711325002272