RE: Senolysis, Reloaded - 5

Zitat von Prometheus im Beitrag #99

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Senolytic compounds reduce epigenetic age of blood samples in vitro
https://www.nature.com/articles/s41514-025-00199-z

Gar nicht so selbstverständlich wie es da geschrieben wird!

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A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease
https://www.sciencedirect.com/science/ar...tr6ra7QOlwbTCIA

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
https://www.nature.com/articles/s41467-0...i7gpnwgQf_NqpdA

Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound
https://onlinelibrary.wiley.com/doi/full...9L-YAD--0nmeY2A

Immunosenescence promotes cancer development: from mechanisms to treatment strategies
https://biosignaling.biomedcentral.com/a...964-025-02082-6

Sex, senescence, senolytics, and cognition
https://pmc.ncbi.nlm.nih.gov/articles/PMC11913825/

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease
.https://www.thelancet.com/journals/ebiom...BsamQHc_Cx6yJwA

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)
https://www.aging-us.com/article/206224/text

@Prometheus NALL (N-Acetyl-L-Leucin) als mögliche Option hier beim Preprint oder?

Senescent cell survival relies on upregulation of lysosomal quality control mechanisms
https://www.biorxiv.org/content/10.1101/...HmwsP9ehp0QiEYQ


Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways
https://pmc.ncbi.nlm.nih.gov/articles/PMC11963325/

High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models
https://www.nature.com/articles/s41467-025-58188-5

Current strategies for senescence treatment: Focused on theranostic performance of nanomaterials
https://www.sciencedirect.com/science/ar...16836592500330X

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.70068

ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role
https://www.sciencedirect.com/science/ar...fu-G6mCHvpVSV2A

Elucidating the Role and Mechanism of Alpha-Enolase in Senescent Amelioration via Metabolic Reprogramming
https://onlinelibrary.wiley.com/doi/10.1111/cpr.70049

Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis
https://stemcellres.biomedcentral.com/ar...287-025-04310-9

Was ist von den weitreichenden Plänen und Ideen von Vince Giuliano zu halten. Hier schreibt er einen neuen Beitrag bzw. eine Zusammenfassung für ein Leben WEIT über 100 Jahre "in bester Vitalität und Gesundheit":
https://www.anti-agingfirewalls.com/2025...gevity-program/

γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis
https://www.biorxiv.org/content/10.1101/..._HLSbOn67oKS4cw

Glucomannogalactan inhibits senescence by promoting nuclear translocation of NRF2
https://pubmed.ncbi.nlm.nih.gov/39961569/

Aging and injury drive neuronal senescence in the dorsal root ganglia
https://www.nature.com/articles/s41593-0...lNNdPzJPajIhFwA


Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products
https://pmc.ncbi.nlm.nih.gov/articles/PMC8004226/

Hinokitiol als mögliches Senolytikum hatten wir mein ich noch nicht.

Functional Features of Senescent Cells and Implications for Therapy
https://www.mdpi.com/1422-0067/26/11/5390

Dietary ingredients inducing cellular senescence in animals and humans: A systematic review
https://www.sciencedirect.com/science/ar...u4qm1Joe0SRi1LQ