RE: Spermidin - 5

The positive effect of spermidine in older adults suffering from dementia after 1 year
https://link.springer.com/article/10.1007/s00508-023-02226-z

Spermidine improves the antioxidant capacity and morphology of intestinal tissues and regulates intestinal microorganisms in Sichuan white geese

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Our results showed that spermidine could increase the ratio of intestinal villus to crypt and improve intestinal morphology. In addition, spermidine can also reduce malondialdehyde (MDA) accumulation caused by 3-NPA by increasing superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activity, thus alleviating intestinal damage. Furthermore, spermidine can regulate intestinal digestive enzyme activities and affect intestinal digestion and absorption ability. Spermidine can also promote an increase in intestinal microbial diversity and abundance and alleviate the change of microflora structure caused by 3-NPA. In conclusion, spermidine promotes the production of beneficial intestinal metabolites such as Wikstromol, Alpha-bisabolol and AS 1–5, thus improving the level of intestinal health. Taken together, these results indicate that spermidine can improve intestinal health by improving intestinal morphology, increasing antioxidant capacity and regulating intestinal flora structure.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824853/

Spermidine ameliorates osteoarthritis via altering macrophage polarization

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Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through anti-apoptosis and anti-inflammation. However, the specific protective mechanism of SPD in osteoarthritis (OA) remains unclear. Here, we explored the role of SPD on the articular cartilage and the synovial tissue, and tested whether the drug would regulate the polarization of synovial macrophages by in vivo and in vitro experiments.
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This work provides new perspectives on the role of SPD in OA. SPD does not directly target chondrocytes, but can ameliorate the degradation of articular cartilage through regulating M1/M2 polarization of synovial macrophages. Hence, SPD is expected to be the potential therapy for OA.

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https://pubmed.ncbi.nlm.nih.gov/38367900/

Spermidine - an old molecule with a new age-defying immune function

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We highlight the effectiveness of spermidine in enhancing antitumor responses in aged animals otherwise nonresponsive to immune checkpoint therapy and propose that spermidine supplementation could be used to enhance the efficacy of anti-PD-1 treatment.

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https://pubmed.ncbi.nlm.nih.gov/37723019/

Gibt es denn inzwischen irgendwo reines Spermidin zu kaufen? Sehr komisch, dass man nur Extrakte mit vergleichsweise niedrigem Gehalt an Spermidin findet.

Zitat von version2 im Beitrag #101

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Gibt es denn inzwischen irgendwo reines Spermidin zu kaufen? Sehr komisch, dass man nur Extrakte mit vergleichsweise niedrigem Gehalt an Spermidin findet.

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Vorsicht bei Spermidin.


Spermidin als potenzieller Biomarker für eine mögliche Alzheimer-Krankheit identifiziert: https://www.uni-greifswald.de/forschung/...-identifiziert/

The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity
https://onlinelibrary.wiley.com/doi/full...xQAsFjjC17oUvmg

Zitat von version2 im Beitrag #102

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Gibt es denn inzwischen irgendwo reines Spermidin zu kaufen? Sehr komisch, dass man nur Extrakte mit vergleichsweise niedrigem Gehalt an Spermidin findet.

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Zitat von Speedy im Beitrag #108

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not4pussy

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Zitat von version2 im Beitrag #109

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Zitat von Speedy im Beitrag #108

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not4pussy

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Dachte erst jemand hätte deinen Account übernommen.
Sieht aber wirklich ganz gut aus, sonst hat man ja nur die 5% Extrakte.

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Zitat von Speedy im Beitrag #110

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Die haben übrigens auch Fisetin als Reinsubstanz.

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Spermidine alleviates depression via control of the stress response
https://www.biorxiv.org/content/10.1101/2024.12.04.626625v1

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification: Implications for DNA Methyltransferase-1 Activity
https://www.sciencedirect.com/science/ar...452302X2400439X

Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
https://www.sciencedirect.com/science/ar...211383525001005

Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage
https://www.sciencedirect.com/science/ar...2316?via%3Dihub

Spermidine mitigates blue-light-induced corneal injury by alleviating oxidative stress and restoring autophagy impairment
https://www.sciencedirect.com/science/ar...014483525001319

The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders
https://www.sciencedirect.com/science/ar...1333?via%3Dihub

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
https://www.nature.com/articles/s41556-0...E2yd75jk_tFwyZA

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These findings suggest that plasma spermidine reflects habitual dietary exposure to a limited extent, whereas skeletal muscle polyamine pools appear to be maintained by strong intracellular regulation.

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Spermidine and spermine in elderly patients with coronary artery disease: a cross-sectional study of dietary intake and plasma and skeletal muscle concentrations
https://www.clinicalnutritionjournal.com...0078-6/fulltext

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These findings suggest that targeting immune cell senescence with Spermidine may improve vaccine responsiveness in older adults and highlight immune-senescence markers as potential predictors of vaccine failure in ageing populations.

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Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study
https://onlinelibrary.wiley.com/doi/10.1111/acel.70545

Spermine is an endogenous iron chelator that inhibits ferroptosis
https://www.nature.com/articles/s41586-0..._a1demo0jtae9sy

Clostridium butyricum and its metabolite spermidine delay cognitive decline during natural brain aging by reducing inflammation and oxidative stress
https://www.sciencedirect.com/science/ar...166432826002299

Spermidin: Studie zeigt Effekte auf Immunabwehr

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Spermidin aktiviert Autophagie

Dabei erwies sich eine tägliche Dosis von 6 mg Spermidin als sicher. Sie aktivierte die Autophagie, sprich zelluläre Reparaturprozesse, und verbesserte die Immunantwort – insbesondere bei älteren Erwachsenen, die anfangs eine sehr schwache Antikörperreaktion zeigten. Die Antikörper konnten auch das Eindringen des Virus in Zellen besser blockieren. Zudem stieg die Anzahl wichtiger Gedächtnis-B-Zellen und Marker der Immunzellalterung wurden reduziert.

Neben seiner Wirkung auf das Immunsystem wird Spermidin in der Wissenschaft intensiv auf seine positiven Effekte bei der Vorbeugung von Herz-Kreislauf-Erkrankungen, beim Schutz vor neurodegenerativen Krankheiten, wie Demenz oder Alzheimer und allgemein zur Verlängerung der gesunden Lebensspanne untersucht.

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https://www.apotheke-adhoc.de/nachrichte...uf-immunabwehr/

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Together, these findings support a unified model in which spermidine-driven autophagy and spermine-mediated ferroptosis inhibition cooperate to preserve tissue homeostasis and healthspan.

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Polyamine-mediated inhibition of ferroptosis contributes to geroprotection
https://pmc.ncbi.nlm.nih.gov/articles/PM...oDLNiXVwZWNGCHA

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Glucocorticoids disrupt bone homeostasis and induce osteoporosis.
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Spermidine (SPD) attenuates bone loss in a Glucocorticoid-induced osteoporosis rat model.
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SPD restores redox balance and reduces oxidative stress.
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SPD suppresses inflammation and modulates RANKL/OPG axis.
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SPD partially preserves bone microarchitecture and turnover markers.

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Spermidine mitigates glucocorticoid-induced bone osteoporosis by targeting oxidative stress and RANKL/OPG pathway
https://www.sciencedirect.com/science/ar...040816626004362