RE: Tipps gegen Falten - 17

Aging in the dermis: Fibroblast senescence and its significance
https://onlinelibrary.wiley.com/doi/full...qt1hfCqtgbQwOqI

Collagen hydrolyzate as a skin rejuvenator | The most effective dose is surprisingly low

Hydrolyzed collagen is a proven cosmeceutical. When it comes to products that keep skin young and healthy, collagen is perhaps the most thoroughly studied supplement. Moreover, according to a Japanese animal study, the effective dose is surprisingly low.

https://ergo-log.com/collagen-hydrolyzat...singly-low.html

Zitat von Tizian im Beitrag #403

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Collagen hydrolyzate as a skin rejuvenator | The most effective dose is surprisingly low

Hydrolyzed collagen is a proven cosmeceutical. When it comes to products that keep skin young and healthy, collagen is perhaps the most thoroughly studied supplement. Moreover, according to a Japanese animal study, the effective dose is surprisingly low.

https://ergo-log.com/collagen-hydrolyzat...singly-low.html

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Klingt damit eher nicht so praxistauglich.

Zitat von Methusalem im Beitrag #405

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Klingt damit eher nicht so praxistauglich.

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Zitat von Methusalem im Beitrag #405

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Klingt damit eher nicht so praxistauglich.

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Zitat von Fichtennadel im Beitrag #407

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Zitat von Methusalem im Beitrag #405

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Klingt damit eher nicht so praxistauglich.

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Äquivalenzdosis ist 1.2G pro 60kg, nicht pro 1kg falls du das meintest. Also durchaus praktikabel.

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Zur Not müsste man die Frage in einem englischsprachigen Forum stellen...

Schönen guten Morgen,
ich verwende eine Östriolcreme fürs Gesicht. Wäre diese effektiv, wenn ich ein paar Tropfen DMSO beimischen würde? es ist die Ovestin-Vaginalcreme.

Anti-aging and rejuvenating effects and mechanism of Dead Sea water in skin
https://onlinelibrary.wiley.com/doi/10.1111/ics.12931

Skin anti-aging strategies

Zitat

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In older skin, collagen looks irregular and disorganized, the ratio of Col-3, to Col-1 has been shown to increase, due, significantly, to a loss of Col-1.29 The overall collagen content per unit area of the skin surface is known to decline approximately 1%/year.30 Glycosaminoglycans (GAGs) are among the primary dermal skin matrix constituents assisting in binding water. In photo-aged skin, GAGs may be associated with abnormal elastotic material and thus be unable to function effectively.31 The total hyaluronic acid (HA) level in the dermis of skin that age intrinsically remains stable; however, epidermal HA diminishes markedly.32

Three primary structural components of the dermis, collagen, elastin and GAGs have been the subjects of the majority of anti-aging research and efforts for aesthetic-anti-aging strategies pertaining to the skin, from ”anti-wrinkle creams” to various filling agents.21

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/

Von den GAGs (Glykosaminoglykane) hatte ich noch nichts gehört, anscheinend kann man da mit Glucosamin nachhelfen.

Das Paper schreibt außerdem recht positiv über die HRT:

Zitat

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Furthermore, another study conducted by Rudman et al. has pointed out that the application of GH decreased the signs of biological aging. The treatment led to an improved body condition, with an increase of muscle mass and osseous density and a decrease of adipose tissue. Moreover, an increase of skin thickness was observed.199

(...)

HRT with testosterone is absolutely indicated in older men who are either symptomatic or have a low serum testosterone level. Either a decrease of testosterone or a loss of the circadian rhythm of testosterone secretion has been observed in a high percentage of older men. Clinical symptoms include general weakness, sexual dysfunction, diminished muscle and bone mass, and decreased erythropoiesis. A low testosterone level has been shown in epidemiological studies to lead to a higher morbidity and mortality rate and to a higher prevalence of depression, coronary heart disease, and osteoporosis. Insulin resistance has been shown to play an important role in the development of hypogonadism in older men. Thus, obese men and men with type 2 diabetes, show significantly lower testosterone levels compared with subjects in control groups.199

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Doch zurück zu Glucosamin:

Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial

Zitat

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Glucosamine sulphate (GS)
(...)
Results: Ex vivo, GS significantly (all p ≤ 0.02) increased the expression of CD44 and collagen type IV, the epidermis GAG level, and collagen type I synthesis. After 8 weeks of oral GS administration, a significantly increased expression was observed at the mRNA level for vimentin, fibromodulin, biglycan, xylosyl transferase, hyaluronan synthase, collagen types I and III, bone morphogenic protein-1, and decorin (all p ≤ 0.05).

Conclusion: Both experiments showed that GS has a positive effect on epidermal and dermal markers associated with age.

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https://pubmed.ncbi.nlm.nih.gov/28214837/

Auch Chondroitin scheint Vorteile für die Haut haben zu können - wenigstens in den Studien. Da ich von Glucosamin und Chondroitin bislang nur im Zusammenhang mit Gelenken und Knorpel gehört hatte, wirft das für mich ein neues Licht auf die beiden Stoffe.

Potential anti-ageing effect of chondroitin sulphate through skin regeneration

Zitat

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Chondroitin sulphate (CS)
(...)
Results: Chondroitin sulphate treatment increased the proliferation of keratinocytes and fibroblasts. It also stimulated the migration and synthesis of ECM components of fibroblasts. Further analysis revealed that CS induced the expression of type I procollagen by activating the extracellular signal-regulated kinase pathway. Using a full-thickness skin wound model and an aged skin model, we confirmed that CS treatment promoted skin wound healing and regeneration.

Conclusion: Together, our results indicated that CS has the potential to facilitate skin regeneration, implying that CS could be clinically applied to improve skin ageing.

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https://pubmed.ncbi.nlm.nih.gov/32583476/

Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis

Zitat

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Here, we report that chondroitin 6-sulfate is important for the maintenance of epidermal homeostasis. Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin permeability barrier function.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835381/

Was meint ihr? Habt ihr die beiden im Stack? Würdet ihr sogar HRT in Betracht ziehen?

Dill Extract Preserves Dermal Elastic Fiber Network and Functionality: Implication of Elafin
https://karger.com/spp/article-abstract/...edFrom=fulltext

Research Progress in Skin Aging and Immunity
https://www.mdpi.com/1422-0067/25/7/4101

Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils

Zitat

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Topical applications of plant oils may have different effect on the skin according to their composition and the pathophysiological context of the skin. The composition varies by different extraction methods. When applied topically, constituents of plant oils (triglycerides, phospholipids, FFAs, phenolic compounds and antioxidants) may act synergistically by several mechanisms: (i) promoting skin barrier homeostasis; (ii) antioxidative activities; (iii) anti-inflammatory properties; (iv) direct and indirect (upregulation of antimicrobial peptides) anti-microbial properties; (v) promoting wound healing; and (vi) anti-carcinogenic properties.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/

Nutzt ihr Pflanzenöle für eure Haut? Falls ja, welche? Wo seht ihr Vor- und Nachteile gegenüber konventioneller Kosmetik?

Vorteil scheint mir zu sein, dass man weiß was drin ist und leichter die Frische/Haltbarkeit überprüfen kann (olfaktorisch).
Nachteile auf jeden Fall dass es je nach Öl schlecht einziehen und man sich die Kleidung verunreinigen könnte (Fettflecken).

Vor einigen Tagen fiel mir auf, dass ich neue Fältchen um den Augenbereich bekommen habe. Zunächst lag der Verdacht nahe, es handelt sich entweder um den normalen Alterungsprozess oder um das Fehlen ausreichender Zufuhr von Kollagen. Inzwischen denke ich jedoch, dass der Grund in einem neuen Pflegeprodukt liegt, welches ich seit einigen Wochen nutze. Dieses enthält bei näherem Hinsehen leider Ethanol.

Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity

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The facts that ethanol is widely used in topical applications and that its adverse effects were seldom reported should not be dismissed. But a confounding factor in any study is the widespread use of alcoholic beverages. However, the prevalent consumption of alcoholic beverages in our society cannot be used as an excuse to completely negate any adverse effect of ethanol in cosmetic or other topical preparations, especially in occupational settings with high exposure to the ethanol containing products. As was pointed out in some of the studies reviewed in this article, the possibility exists that on the point of impact, very high concentrations of ethanol and acetaldehyde may cause chronic toxic effects. The effects may be more pronounced in ALDH-deficient humans, but this association demands further research.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596158/

Das ist so ein Fall von: Theoretisch kein Problem, praktisch erlebe ich aber negative Auswirkungen dadurch. Wenigstens ist die zeitliche Korrelation gegeben. In Zukunft setze ich wieder auf Pflanzenöle oder eigene Mischungen.

Gehen die Falten dann wieder weg?

Zitat von Tizian im Beitrag #417

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Gehen die Falten dann wieder weg?

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Zitat von version2 im Beitrag #418

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Zitat von Tizian im Beitrag #417

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Gehen die Falten dann wieder weg?

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Meine Glaskugel ist gerade nicht auffindbar. Ich berichte dir einfach, wie es sich entwickelt.
Selbst wenn nicht, jedenfalls will ich keine weiteren Schäden in Kauf nehmen.

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Innerlich angewendet sieht man Alkohol an der Haut. Äuserlich nehme ich ihn gerne zum desinfizieren. Wie sehen eure Handrücken aus nach 3 Jahren Dauer Desinfektion bei Corona?
Planzenöl nahm/nehme ich Olivenöl mit Jojobaöl(Wachs).
Es befeuchtet die Haut nicht gut. Ich nehme dazu zwar noch einen Wasserspray (H2, Ascorbinsäure, Mg) aber so viel bringt das nicht. Wenn es spannt braucht man eine Creme.
Empfindliche Öle würde ich direkt aus den Samen pressen aber ich habe zu wenig Lust und Zeit für so was.

Nicht getestet.

Ferulasäure

Zitat

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Ferulasäure (genauer trans-Ferulasäure) ist eine organische Verbindung, die (oder deren Ester) in verschiedenen Pflanzen, z. B. Stinkasant, Dill, Reis oder Süßgräsern wie Weizen oder Gerste, vorkommt (siehe auch die Pflanzengattung Ferula). Sie spielt eine Rolle bei der Synthese von Lignin in den Zellwänden der Pflanzen.[5]

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https://de.wikipedia.org/wiki/Ferulas%C3%A4ure

What Is Ferulic Acid?

Zitat

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Ferulic acid is an organic compound found in anti-aging skin creams and serums. It is also a dietary supplement. Some studies suggest it can neutralize free radicals, unstable molecules that damage and age cells.1

Topical application (on the skin) of ferulic acid aims to protect the skin from aging, sun damage, and skin cancer. As a supplement, some researchers have cited it as a potential treatment for Alzheimer's disease, diabetes, and other health conditions.2

However, all research on ferulic acid is in its early stages. Assuring its safety and effectiveness for general use will require much more.

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https://www.verywellhealth.com/the-benef...ulic-acid-89607

Effects of regular exercise on skin moisturizing function in adults

Zitat

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These results suggest that regular exercise may help maintain and improve skin moisturizing function.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774845/

The Potential of Exercise on Lifestyle and Skin Function: Narrative Review

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Regular exercise is associated with increased blood flow to the skin, elevated skin temperature, and improved skin moisture. Furthermore, it has been shown to improve skin structure and rejuvenate its appearance, possibly through promoting mitochondrial biosynthesis and affecting hormone secretion. Further research is needed to understand the effects of different amounts and content of exercise on the skin.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979338/

Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices

Zitat

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AT and RT had different effects on circulating levels of factors, such as cytokines, hormones in serum, and metabolites, and RT increased dermal biglycan (BGN). To our knowledge, this is the first report to show different effects of AT and RT on skin aging and identify the key factors involved in RT-induced skin rejuvenation.

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https://www.nature.com/articles/s41598-023-37207-9

Kommentar: AT = Aerobic training, RT = Resistance training. Also in etwa: Kardio vs. Kraftsport.

Mir fehlt gerade Kardio. Kraftsport wirkt einfach anders und die Entgiftung ist subjektiv nicht so stark wie z.B. beim Joggen.

Establishing the Inhibition of the Serine Protease Plasmin as a Skin Anti-Aging Pathway
https://www.mdpi.com/2079-9284/11/3/103

Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin
https://onlinelibrary.wiley.com/doi/10.1111/jdv.19820

Zitat von Speedy im Beitrag #423

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Serine Protease Plasmin

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Schönen guten Morgen,

gegen Falten nutze ich am Morgen meine Estriolcreme gemischt mit MSM Gel und DMSO und am Abend Rhizinusöl gemischt mit MSM Gel und DMSO.

Die Wirkung ist supergut. Zudem nehme ich viel Vitamin C und Methylenblau für die Kollagenbildung innerlich ein.

Bin ja schon fast 60 und wurde jetzt schon 2 Mal für die Schwester meiner jüngsten Tochter gehalten. Scheint also zu wirken :-)

Liebe Grüße von Julie